-Heterocyclic Carbene Iron Complexes As Anticancer Agents: In Vitro and In Vivo Biological Studies

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Sep 28

PMID 34577006

Citations 5

Authors

Oscar A Lenis-Rojas

Sandra Cordeiro

Marta Horta-Meireles

Jhonathan Angel Araujo Fernandez

Sabela Fernandez Vila

Juan Andres Rubiolo

Pablo Cabezas-Sainz

Laura Sanchez

Alexandra R Fernandes

Beatriz Royo

Affiliations

Soon will be listed here.

Abstract

Cisplatin and its derivatives are commonly used in chemotherapeutic treatments of cancer, even though they suffer from many toxic side effects. The problems that emerge from the use of these metal compounds led to the search for new complexes capable to overcome the toxic side effects. Here, we report the evaluation of the antiproliferative activity of Fe(II) cyclopentadienyl complexes bearing -heterocyclic carbene ligands in tumour cells and their in vivo toxicological profile. The in vitro antiproliferative assays demonstrated that complex displays the highest cytotoxic activity both in human colorectal carcinoma cells (HCT116) and ovarian carcinoma cells (A2780) with IC values in the low micromolar range. The antiproliferative effect of was even higher than cisplatin. Interestingly, showed low in vivo toxicity, and in vivo analyses of and compounds using colorectal HCT116 zebrafish xenograft showed that both reduce the proliferation of human HCT116 colorectal cancer cells in vivo.

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