Alexandra R Fernandes
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Explore the profile of Alexandra R Fernandes including associated specialties, affiliations and a list of published articles.
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Articles
146
Citations
2658
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Recent Articles
1.
Lenis-Rojas O, Roma-Rodrigues C, Roma C, Carvalho B, Andrade V, Friaes S, et al.
Chempluschem
. 2025 Feb;
:e202400775.
PMID: 39954229
The first examples of Ru(II) η-arene (benzene and p-cymene) complexes containing a bidentate triazolylidene-triazolide ligand have been prepared and fully characterized. Their antiproliferative effect has been investigated against tumour cells...
2.
Braga C, Ferreira-Silva M, Corvo M, Moreira R, Fernandes A, Vaz J, et al.
RSC Med Chem
. 2025 Jan;
PMID: 39850550
Hypoxia is a hallmark of the glioblastoma multiforme microenvironment and represents a promising therapeutic target for cancer treatment. Herein, we report nitroaromatic-based triazene prodrugs designed for selective activation by tumoral...
3.
Cordeiro S, Oliveira B, Valente R, Ferreira D, Luz A, Baptista P, et al.
Front Cell Dev Biol
. 2024 Dec;
12:1507388.
PMID: 39659521
Despite extensive efforts to unravel tumor behavior and develop anticancer therapies, most treatments fail when advanced to clinical trials. The main challenge in cancer research has been the absence of...
4.
Choroba K, Zowislok B, Kula S, Machura B, Maron A, Erfurt K, et al.
J Med Chem
. 2024 Nov;
67(21):19475-19502.
PMID: 39496093
Cu(II) complexes with 2,2':6',2″-terpyridines (terpy) and 2,6-bis(thiazol-2-yl)pyridines (dtpy) with 1- or 2-naphtyl and methoxy-naphtyl were synthesized to elucidate the impact of the triimine core, naphtyl linking mode, and presence of...
5.
Bravo A, Morao B, Luz A, Dourado R, Oliveira B, Guedes A, et al.
Cancers (Basel)
. 2024 Oct;
16(20).
PMID: 39456638
Background/objectives: Pancreatic ductal adenocarcinoma (PDAC) incidence is rising, and prognosis remains poor due to late diagnosis and limited effective therapies. Currently, patients are treated based on TNM staging, without molecular...
6.
Mauricio E, Branco P, Araujo A, Roma-Rodrigues C, Lima K, Duarte M, et al.
Antibiotics (Basel)
. 2024 Sep;
13(9).
PMID: 39335054
Biotechnological active peptides are gaining interest in the cosmetics industry due to their antimicrobial, anti-inflammatory, antioxidant, and anti-collagenase (ACE) effects, as well as wound healing properties, making them suitable for...
7.
Reigosa-Chamorro F, Cordeiro S, Pereira M, Filipe B, Baptista P, Fernandes A, et al.
Dalton Trans
. 2024 Sep;
53(44):17803-17818.
PMID: 39233530
Herein, we describe the synthesis and characterization of a series of thiosemicarbazone platinacycles. Their activity towards HCT116 and A2780 cancer cell lines as well as normal fibroblasts was explored and...
8.
Paquete-Ferreira J, Freire F, Fernandes H, Muthukumaran J, Ramos J, Bryton J, et al.
Front Chem
. 2024 Aug;
12:1379914.
PMID: 39170866
The rise of antibiotic-resistant bacterial strains has become a critical health concern. According to the World Health Organization, the market introduction of new antibiotics is alarmingly sparse, underscoring the need...
9.
Idiago-Lopez J, Ferreira D, Asin L, Moros M, Armenia I, Grazu V, et al.
Nanoscale
. 2024 Jul;
16(32):15176-15195.
PMID: 39052238
In this work, we report the disruptive use of membrane-localized magnetic hyperthermia to promote the internalization of cell-impermeant probes. Under an alternating magnetic field, magnetic nanoparticles (MNPs) immobilized on the...
10.
Cunha J, Roma-Rodrigues C, Ferreira J, Baptista P, Fernandes A, Guieu S, et al.
ChemMedChem
. 2024 Jun;
19(20):e202400225.
PMID: 38880774
Azaindole scaffold is a privileged structure in medicinal chemistry and some derivatives have demonstrated to be potential anticancer drugs. Herein, a set of novel azaindoles, comprising the four regioisomers, bearing...