Communications Between Mitochondria and Endoplasmic Reticulum in the Regulation of Metabolic Homeostasis

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2021 Sep 28

PMID 34571844

Citations 14

Authors

Pengcheng Zhang

Daniels Konja

Yiwei Zhang

Yu Wang

Affiliations

Soon will be listed here.

Abstract

Mitochondria associated membranes (MAM), which are the contact sites between endoplasmic reticulum (ER) and mitochondria, have emerged as an important hub for signaling molecules to integrate the cellular and organelle homeostasis, thus facilitating the adaptation of energy metabolism to nutrient status. This review explores the dynamic structural and functional features of the MAM and summarizes the various abnormalities leading to the impaired insulin sensitivity and metabolic diseases.

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References

Chavez J, Knotts T, Wang L, Li G, Dobrowsky R, Florant G . A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem. 2003; 278(12):10297-303. DOI: 10.1074/jbc.M212307200. View

McLelland G, Goiran T, Yi W, Dorval G, Chen C, Lauinger N . Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. Elife. 2018; 7. PMC: 5927771. DOI: 10.7554/eLife.32866. View

Stoica R, De Vos K, Paillusson S, Mueller S, Sancho R, Lau K . ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43. Nat Commun. 2014; 5:3996. PMC: 4046113. DOI: 10.1038/ncomms4996. View

Ramos-Lopez O, Riezu-Boj J, Milagro F, Moreno-Aliaga M, Martinez J . Endoplasmic reticulum stress epigenetics is related to adiposity, dyslipidemia, and insulin resistance. Adipocyte. 2018; 7(2):137-142. PMC: 6152516. DOI: 10.1080/21623945.2018.1447731. View

Herrera-Cruz M, Simmen T . Over Six Decades of Discovery and Characterization of the Architecture at Mitochondria-Associated Membranes (MAMs). Adv Exp Med Biol. 2017; 997:13-31. DOI: 10.1007/978-981-10-4567-7_2. View

Ozcan U, Cao Q, Yilmaz E, Lee A, Iwakoshi N, Ozdelen E . Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. 2004; 306(5695):457-61. DOI: 10.1126/science.1103160. View

Martins de Brito O, Scorrano L . Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature. 2008; 456(7222):605-10. DOI: 10.1038/nature07534. View

Bansaghi S, Golenar T, Madesh M, Csordas G, RamachandraRao S, Sharma K . Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species. J Biol Chem. 2014; 289(12):8170-81. PMC: 3961646. DOI: 10.1074/jbc.M113.504159. View

Theurey P, Tubbs E, Vial G, Jacquemetton J, Bendridi N, Chauvin M . Mitochondria-associated endoplasmic reticulum membranes allow adaptation of mitochondrial metabolism to glucose availability in the liver. J Mol Cell Biol. 2016; 8(2):129-43. DOI: 10.1093/jmcb/mjw004. View

10.

Zhao R, Jiang S, Zhang L, Yu Z . Mitochondrial electron transport chain, ROS generation and uncoupling (Review). Int J Mol Med. 2019; 44(1):3-15. PMC: 6559295. DOI: 10.3892/ijmm.2019.4188. View

11.

Ni H, Williams J, Ding W . Mitochondrial dynamics and mitochondrial quality control. Redox Biol. 2014; 4:6-13. PMC: 4309858. DOI: 10.1016/j.redox.2014.11.006. View

12.

Hou T, Zhang X, Xu J, Jian C, Huang Z, Ye T . Synergistic triggering of superoxide flashes by mitochondrial Ca2+ uniport and basal reactive oxygen species elevation. J Biol Chem. 2013; 288(7):4602-12. PMC: 3576066. DOI: 10.1074/jbc.M112.398297. View

13.

Gomez-Suaga P, Paillusson S, Stoica R, Noble W, Hanger D, Miller C . The ER-Mitochondria Tethering Complex VAPB-PTPIP51 Regulates Autophagy. Curr Biol. 2017; 27(3):371-385. PMC: 5300905. DOI: 10.1016/j.cub.2016.12.038. View

14.

Marty I . Triadin regulation of the ryanodine receptor complex. J Physiol. 2015; 593(15):3261-6. PMC: 4553051. DOI: 10.1113/jphysiol.2014.281147. View

15.

Thivolet C, Vial G, Cassel R, Rieusset J, Madec A . Reduction of endoplasmic reticulum- mitochondria interactions in beta cells from patients with type 2 diabetes. PLoS One. 2017; 12(7):e0182027. PMC: 5526536. DOI: 10.1371/journal.pone.0182027. View

16.

Lee K, Huh S, Lee S, Wu Z, Kim A, Kang H . Altered ER-mitochondria contact impacts mitochondria calcium homeostasis and contributes to neurodegeneration in vivo in disease models. Proc Natl Acad Sci U S A. 2018; 115(38):E8844-E8853. PMC: 6156612. DOI: 10.1073/pnas.1721136115. View

17.

Anastasia I, Ilacqua N, Raimondi A, Lemieux P, Ghandehari-Alavijeh R, Faure G . Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis. Cell Rep. 2021; 34(11):108873. DOI: 10.1016/j.celrep.2021.108873. View

18.

Theurey P, Rieusset J . Mitochondria-Associated Membranes Response to Nutrient Availability and Role in Metabolic Diseases. Trends Endocrinol Metab. 2016; 28(1):32-45. DOI: 10.1016/j.tem.2016.09.002. View

19.

De Stefani D, Rizzuto R, Pozzan T . Enjoy the Trip: Calcium in Mitochondria Back and Forth. Annu Rev Biochem. 2016; 85:161-92. DOI: 10.1146/annurev-biochem-060614-034216. View

20.

Park S, Lee S, Suh Y, Kim S, Lee N, Hong J . DISC1 Modulates Neuronal Stress Responses by Gate-Keeping ER-Mitochondria Ca Transfer through the MAM. Cell Rep. 2017; 21(10):2748-2759. DOI: 10.1016/j.celrep.2017.11.043. View