The Effect of Paternal Age on Intracytoplasmic Sperm Injection Outcome in Unexplained Infertility

Overview

Journal Arab J Urol

Date 2021 Sep 23

PMID 34552779

Citations 1

Authors

Haitham Elbardisi

Mohamed Arafa

Neha Singh

Bridget Betts

Ashok Agrawal

Ralf Henkel

Alia A Al-Hadi

Hasan Burjaq

Alia Alattar

Kareim Khalafalla

Ahmad Majzoub

Affiliations

Soon will be listed here.

Abstract

Objective: : To examine the effect of paternal age on intracytoplasmic sperm injection (ICSI) outcomes in unexplained infertility.

Subjects And Methods: : This retrospective study, done at the Hamad Medical Corporation, Doha, Qatar screened infertile couples who underwent ICSI between 2014 and 2019 for the inclusion and exclusion criteria defining 'unexplained infertility'. Couples recruited were allocated into two groups: Group A (paternal age <35 years) and Group B (paternal age ≥35 years). Baseline characteristics, investigations including semen and advanced sperm function tests and ICSI records were compared for primary outcomes such as fertilisation, cleavage, clinical pregnancy, miscarriage and live birth; and secondary outcomes such as semen parameters and advanced sperm functions (DNA fragmentation index and oxidation reduction potential).

Results: : We found that final pregnancy outcomes including clinical pregnancy rate ( = 0.231), live-birth rate ( = 0.143), and miscarriage rates ( = 0.466) were not significantly different between the two age groups. Normal fertilisation ( = 0.01) and cleavage rate after ICSI ( = 0.001) were statistically significant when the age groups were compared. Also, normal sperm morphology was found to be significantly different ( = 0.041).

Conclusions: : Advanced paternal age affects sperm morphology, fertilisation and embryo cleavage in ICSI but does not appear to affect clinical pregnancy, miscarriage or live-birth rates. ICSI appears to be a valid fertility treatment option in advancing paternal age.

Citing Articles

Livebirth rates are influenced by an interaction between male and female partners' age: analysis of 59 951 fresh IVF/ICSI cycles with and without male infertility.

Datta A, Campbell S, Diaz-Fernandez R, Nargund G Hum Reprod. 2024; 39(11):2491-2500.

PMID: 39241250 PMC: 11532605. DOI: 10.1093/humrep/deae198.

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