Monocyte to High-density Lipoprotein Cholesterol Ratio As an Independent Risk Factor for Papillary Thyroid Carcinoma

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2021 Sep 21

PMID 34545629

Citations 10

Authors

Hongzhi Xu

Yufeng Pang

Xueqing Li

Bingbing Zha

Tao He

Heyuan Ding

Affiliations

Soon will be listed here.

Abstract

Background: Papillary thyroid carcinoma (PTC) is considered to be an inflammatory disease. This study aimed to investigate the association of monocyte to high-density lipoprotein cholesterol ratio (MHR) with PTC.

Methods: Clinical parameters from 300 patients with PTC and 552 patients with benign thyroid nodule were compared. Serum renal function and liver enzymes, fasting plasma glucose, lipid profile, and blood cell count were measured.

Results: Patients with PTC had a higher MONO (p < 0.001) and MHR (p < 0.001). There was a step-wise increase in the prevalence of PTC (p = 0.003) with the tertile of MHR. Logistic regression analysis revealed that MHR could be considered an independent risk factor (p < 0.001) in the case-control study and the cohort study. Pearson correlation analysis and simple linear regression analysis indicated that MHR was positively associated with neutrophil (NEU) and lymphocyte (LYM) count as well as neutrophil-to-lymphocyte ratio (NLR). Area under the curve (AUC) was 0.711. The optimal cutoff of MHR was 0.33 × 10 /mmol.

Conclusion: This study identifies novel evidence that patients with PTC have a higher MHR. MHR is an independent risk factor for PTC. These findings support the application of MHR to predict, diagnose, and evaluate the occurrence of PTC.

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References

Guarino V, Castellone M, Avilla E, Melillo R . Thyroid cancer and inflammation. Mol Cell Endocrinol. 2009; 321(1):94-102. DOI: 10.1016/j.mce.2009.10.003. View

Ekizler F, Cay S, Acar B, Tak B, Kafes H, Ozeke O . Monocyte to high-density lipoprotein cholesterol ratio predicts adverse cardiac events in patients with hypertrophic cardiomyopathy. Biomark Med. 2019; 13(14):1175-1186. DOI: 10.2217/bmm-2019-0089. View

Zhang Y, Wang Q, Chen Y, Shen C, Xu C . Association between Serum Uric Acid to HDL-Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Lean Chinese Adults. Int J Endocrinol. 2020; 2020:5953461. PMC: 7125489. DOI: 10.1155/2020/5953461. View

Ganjali S, Momtazi A, Banach M, Kovanen P, Stein E, Sahebkar A . HDL abnormalities in familial hypercholesterolemia: Focus on biological functions. Prog Lipid Res. 2017; 67:16-26. DOI: 10.1016/j.plipres.2017.05.001. View

Aktas G, Sit M, Karagoz I, Erkus E, Ozer B, Kocak M . Could Red Cell Distribution Width be a Marker of Thyroid Cancer?. J Coll Physicians Surg Pak. 2017; 27(9):556-558. DOI: 2699. View

Xu H, Pang Y, Li X, Zha B, He T, Ding H . Monocyte to high-density lipoprotein cholesterol ratio as an independent risk factor for papillary thyroid carcinoma. J Clin Lab Anal. 2021; 35(11):e24014. PMC: 8605115. DOI: 10.1002/jcla.24014. View

Kurtkulagi O, Atak Tel B, Kahveci G, Bilgin S, Duman T, Erturk A . Hashimoto's thyroiditis is associated with elevated serum uric acid to high density lipoprotein-cholesterol ratio. Rom J Intern Med. 2021; 59(4):403-408. DOI: 10.2478/rjim-2021-0023. View

Sit M, Aktas G, Erkol H, Yaman S, Keyif F, Savli H . Neutrophil to Lymphocyte Ratio is Useful in Differentiation of Malign and Benign Thyroid Nodules. P R Health Sci J. 2019; 38(1):60-63. View

Puhm F, Afonyushkin T, Resch U, Obermayer G, Rohde M, Penz T . Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells. Circ Res. 2019; 125(1):43-52. DOI: 10.1161/CIRCRESAHA.118.314601. View

10.

Song L, Zhu J, Li Z, Wei T, Gong R, Lei J . The prognostic value of the lymphocyte-to-monocyte ratio for high-risk papillary thyroid carcinoma. Cancer Manag Res. 2019; 11:8451-8462. PMC: 6756579. DOI: 10.2147/CMAR.S219163. View

11.

Selvaggio S, Abate A, Brugaletta G, Musso C, Di Guardo M, Di Guardo C . Platelet‑to‑lymphocyte ratio, neutrophil‑to‑lymphocyte ratio and monocyte‑to‑HDL cholesterol ratio as markers of peripheral artery disease in elderly patients. Int J Mol Med. 2020; 46(3):1210-1216. DOI: 10.3892/ijmm.2020.4644. View

12.

Aktas G, Kocak M, Bilgin S, Atak B, Duman T, Kurtkulagi O . Uric acid to HDL cholesterol ratio is a strong predictor of diabetic control in men with type 2 diabetes mellitus. Aging Male. 2019; 23(5):1098-1102. DOI: 10.1080/13685538.2019.1678126. View

13.

Kocak M, Aktas G, Erkus E, Sincer I, Atak B, Duman T . Serum uric acid to HDL-cholesterol ratio is a strong predictor of metabolic syndrome in type 2 diabetes mellitus. Rev Assoc Med Bras (1992). 2019; 65(1):9-15. DOI: 10.1590/1806-9282.65.1.9. View

14.

Park S, Zhu J, Altan-Bonnet G, Cheng S . Monocyte recruitment and activated inflammation are associated with thyroid carcinogenesis in a mouse model. Am J Cancer Res. 2019; 9(7):1439-1453. PMC: 6682719. View

15.

Bolayir A, Gokce S, Cigdem B, Bolayir H, Yildiz O, Bolayir E . Monocyte/high-density lipoprotein ratio predicts the mortality in ischemic stroke patients. Neurol Neurochir Pol. 2017; 52(2):150-155. DOI: 10.1016/j.pjnns.2017.08.011. View

16.

Onalan E . The relationship between monocyte to high-density lipoprotein cholesterol ratio and diabetic nephropathy. Pak J Med Sci. 2019; 35(4):1081-1086. PMC: 6659096. DOI: 10.12669/pjms.35.4.534. View

17.

Xie Z, Li X, He Y, Wu S, Wang S, Sun J . Immune Cell Confrontation in the Papillary Thyroid Carcinoma Microenvironment. Front Endocrinol (Lausanne). 2020; 11:570604. PMC: 7642595. DOI: 10.3389/fendo.2020.570604. View

18.

Dincgez Cakmak B, Dundar B, Ketenci Gencer F, Aydin B, Yildiz D . TWEAK and monocyte to HDL ratio as a predictor of metabolic syndrome in patients with polycystic ovary syndrome. Gynecol Endocrinol. 2018; 35(1):66-71. DOI: 10.1080/09513590.2018.1490401. View

19.

Kim K, Pak K, Kim I, Kim M, Kim B, Lee B . Lymphocyte-to-monocyte ratio prior to radioiodine ablation in low- and intermediate-risk, papillary thyroid cancer. Endocrine. 2020; 70(2):364-371. DOI: 10.1007/s12020-020-02328-y. View

20.

Akboga M, Balci K, Maden O, Goktug Ertem A, Kirbas O, Yayla C . Usefulness of monocyte to HDL-cholesterol ratio to predict high SYNTAX score in patients with stable coronary artery disease. Biomark Med. 2016; 10(4):375-83. DOI: 10.2217/bmm-2015-0050. View