» Articles » PMID: 34498161

Heat Shock Proteins with an Emphasis on HSP 60

Overview
Journal Mol Biol Rep
Specialty Molecular Biology
Date 2021 Sep 9
PMID 34498161
Citations 14
Authors
Affiliations
Soon will be listed here.
Abstract

Heat shock phenomenon is a process by which cells express a set of proteins called heat shock proteins (HSPs) against heat stress. HSPs include several families depending upon the molecular weight of the respective protein. Among the different HSPs, The HSP60 is one of the main components representing the framework of chaperone system. HSP60 plays a myriad number of roles like chaperoning, thermotolerance, apoptosis, cancer, immunology and embryonic development. In this review we discussed briefly the general knowledge and focussed on HSP60 in terms of structure, regulation and function in various physiological and pathological conditions.

Citing Articles

Hyperthermia and targeting heat shock proteins: innovative approaches for neurodegenerative disorders and Long COVID.

Smadja D, Abreu M Front Neurosci. 2025; 19:1475376.

PMID: 39967803 PMC: 11832498. DOI: 10.3389/fnins.2025.1475376.


More than Just Protein Folding: The Epichaperome, Mastermind of the Cancer Cell.

Amissah H, Antwi M, Amissah T, Combs S, Shevtsov M Cells. 2025; 14(3).

PMID: 39936995 PMC: 11817126. DOI: 10.3390/cells14030204.


The Genetics and Breeding of Heat Stress Tolerance in Wheat: Advances and Prospects.

Zheng Y, Cai Z, Wang Z, Maruza T, Zhang G Plants (Basel). 2025; 14(2).

PMID: 39861500 PMC: 11768744. DOI: 10.3390/plants14020148.


HSP60 controls mitochondrial ATP generation for optimal virus-specific IL-21-producing CD4 and cytotoxic CD8 memory T cell responses.

Ghahari N, Shegefti S, Alaei M, Amara A, Telittchenko R, Isnard S Commun Biol. 2024; 7(1):1688.

PMID: 39709477 PMC: 11663223. DOI: 10.1038/s42003-024-07326-8.


Structural Stability Comparisons Between Natural and Engineered Group II Chaperonins: Are Crenarchaeal "Heat Shock" Proteins Also "pH Shock" Resistant?.

Furr M, Badiee S, Basha S, Agrawal S, Alraawi Z, Heng S Microorganisms. 2024; 12(11).

PMID: 39597738 PMC: 11596651. DOI: 10.3390/microorganisms12112348.


References
1.
Feder M, Hofmann G . Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. Annu Rev Physiol. 1999; 61:243-82. DOI: 10.1146/annurev.physiol.61.1.243. View

2.
TISSIERES A, MITCHELL H, Tracy U . Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs. J Mol Biol. 1974; 84(3):389-98. DOI: 10.1016/0022-2836(74)90447-1. View

3.
Hemmingsen S, Woolford C, Van Der Vies S, Tilly K, Dennis D, Georgopoulos C . Homologous plant and bacterial proteins chaperone oligomeric protein assembly. Nature. 1988; 333(6171):330-4. DOI: 10.1038/333330a0. View

4.
Chen B, Feder M, Kang L . Evolution of heat-shock protein expression underlying adaptive responses to environmental stress. Mol Ecol. 2018; 27(15):3040-3054. DOI: 10.1111/mec.14769. View

5.
An Y, Rowland S, Na J, Spigolon D, Hong S, Yoon Y . Structural and mechanistic characterization of an archaeal-like chaperonin from a thermophilic bacterium. Nat Commun. 2017; 8(1):827. PMC: 5635000. DOI: 10.1038/s41467-017-00980-z. View