» Articles » PMID: 34490888

Deep Learning for Bioimage Analysis in Developmental Biology

Overview
Journal Development
Specialty Biology
Date 2021 Sep 7
PMID 34490888
Citations 21
Authors
Affiliations
Soon will be listed here.
Abstract

Deep learning has transformed the way large and complex image datasets can be processed, reshaping what is possible in bioimage analysis. As the complexity and size of bioimage data continues to grow, this new analysis paradigm is becoming increasingly ubiquitous. In this Review, we begin by introducing the concepts needed for beginners to understand deep learning. We then review how deep learning has impacted bioimage analysis and explore the open-source resources available to integrate it into a research project. Finally, we discuss the future of deep learning applied to cell and developmental biology. We analyze how state-of-the-art methodologies have the potential to transform our understanding of biological systems through new image-based analysis and modelling that integrate multimodal inputs in space and time.

Citing Articles

Machine learning approaches for image classification in developmental biology and clinical embryology.

Mapstone C, Plusa B Development. 2025; 152(4).

PMID: 39960146 PMC: 11883239. DOI: 10.1242/dev.202066.


Novel imaging and biophysical approaches to study tissue hydraulics in mammalian folliculogenesis.

Turley J, Leong K, Chan C Biophys Rev. 2024; 16(5):625-637.

PMID: 39618785 PMC: 11604877. DOI: 10.1007/s12551-024-01231-4.


Nuclear instance segmentation and tracking for preimplantation mouse embryos.

Nunley H, Shao B, Denberg D, Grover P, Singh J, Avdeeva M Development. 2024; 151(21).

PMID: 39373366 PMC: 11574361. DOI: 10.1242/dev.202817.


Deep 3D histology powered by tissue clearing, omics and AI.

Erturk A Nat Methods. 2024; 21(7):1153-1165.

PMID: 38997593 DOI: 10.1038/s41592-024-02327-1.


Virtual tissue microstructure reconstruction across species using generative deep learning.

Bettancourt N, Perez-Gallardo C, Candia V, Guevara P, Kalaidzidis Y, Zerial M PLoS One. 2024; 19(7):e0306073.

PMID: 38995963 PMC: 11244806. DOI: 10.1371/journal.pone.0306073.


References
1.
Doan M, Sebastian J, Caicedo J, Siegert S, Roch A, Turner T . Objective assessment of stored blood quality by deep learning. Proc Natl Acad Sci U S A. 2020; 117(35):21381-21390. PMC: 7474613. DOI: 10.1073/pnas.2001227117. View

2.
Schneider C, Rasband W, Eliceiri K . NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 2012; 9(7):671-5. PMC: 5554542. DOI: 10.1038/nmeth.2089. View

3.
Paternot G, Devroe J, Debrock S, DHooghe T, Spiessens C . Intra- and inter-observer analysis in the morphological assessment of early-stage embryos. Reprod Biol Endocrinol. 2009; 7:105. PMC: 2761923. DOI: 10.1186/1477-7827-7-105. View

4.
Zhang Z, Wang Q, Ke Y, Liu S, Ju J, Lim W . Design of Tunable Oscillatory Dynamics in a Synthetic NF-κB Signaling Circuit. Cell Syst. 2017; 5(5):460-470.e5. DOI: 10.1016/j.cels.2017.09.016. View

5.
Young H, Belbut B, Baeta M, Petreanu L . Laminar-specific cortico-cortical loops in mouse visual cortex. Elife. 2021; 10. PMC: 7877907. DOI: 10.7554/eLife.59551. View