Patient-reported Quality of Life with Interstitial Partial Breast Brachytherapy and External Beam Whole Breast Radiotherapy: a Comparison Using Propensity-score Matching

Overview

Journal J Contemp Brachytherapy

Date 2021 Sep 6

PMID 34484352

Citations 4

Authors

Tabassum Wadasadawala

Priyamvada Maitre

Shwetabh Sinha

Vani Parmar

Rima Pathak

Mithila Gaikar

Shalini Verma

Rajiv Sarin

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim of this study was to compare patient-reported quality of life (QOL) scores after accelerated partial breast irradiation (APBI) using interstitial brachytherapy vs. external beam whole breast radiotherapy (WBRT) for breast cancer.

Material And Methods: Women with breast cancer treated with WBRT or APBI after breast conservation surgery were enrolled in this prospective study. Single cross-sectional QOL assessment was performed using EORTC QLQ-C30 and BR-23 questionnaires. Patients treated with APBI were propensity-score matched to similar cohort of patients treated with WBRT. QOL scores were analyzed for the entire unmatched cohort and compared between the two matched cohorts using Student's two-tailed -test. -value of < 0.05 was considered statistically significant, and a 10-point difference between mean scores was considered clinically meaningful.

Results: A total of 64 APBI patients were matched with 99 WBRT patients out of the entire study cohort of 320 cases. QOL scores for functional scales of QLQ-C30 were similar between the two groups for both matched and unmatched cohorts, while symptom scores of QLQ-C30 did not show any clinically significant difference. Functional scales of BR-23 did not show any clinical or statistically significant difference. Among symptom scales of BR-23, scores were similar for APBI and WBRT groups except for a worse score of "upset by hair loss" sub-scale in the brachytherapy group of the matched cohort (51.9 vs. 22.7, = 0.006).

Conclusions: Patients undergoing APBI reported similar QOL compared to WBRT when matched for various factors.

Citing Articles

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