The Combined Effects of Age and HIV on the Anatomic Distribution of Cortical and Cancellous Bone in the Femoral Neck Among Men and Women

Overview

Journal AIDS

Specialty Infectious Diseases

Date 2021 Sep 5

PMID 34482349

Citations 1

Authors

Alison G Abraham

Jing Sun

Anjali Sharma

Michael T Yin

J Keenan Brown

Shadpour Demehri

Joshua Garza

Jayesh G Shah

Frank J Palella

Lawrence Kingsley

Beth D Jamieson

Keri N Althoff

Todd T Brown

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate HIV-related and age-related differences in hip bone structure in men and women.

Design: Cross sectional study of bone structure and HIV serostatus.

Methods: We used Quantitative Computed Tomography (QCT) data from the Multicenter AIDS Cohort Study (MACS) and Women's Interagency HIV Study (WIHS) to examine cortical thickness (CT) and cortical (CBMD), trabecular (TBMD), and integral (IBMD) bone mineral density across anatomic quadrants of the femoral neck in older adult MSM and women with (PWH) and without (PWOH) HIV infection. The percentage difference (%diff) in the means for CT and BMD overall and by quadrant between PWH and PWOH were estimated.

Results: Among 322 MSM (median age 60 years) with bone measures, distributions were similar between HIV serostatus groups with %diff in the quadrant means ranging from -7 to -1% for CT and from -1 to 4% for BMD, and overall lower hip cortical thickness than expected. In contrast, in 113 women (median age 51 years), PWH had lower CT, IBMD and TBMD consistently across all quadrants, with differences ranging from -10 to -20% for CT, -6 to -11% for IBMD and -3 to -6% for TBMD. Estimates reached statistical significance in superoanterior quadrant for CT and IBMD and inferoposterior for CT.

Conclusion: Among women, PWH appear to have a thinner cortex and less dense integral bone compared with PWOH, particularly in the superior quadrants whereas MSM overall had a thinner than expected hip cortex.

Citing Articles

Bone Quality in Relation to HIV and Antiretroviral Drugs.

Olali A, Carpenter K, Myers M, Sharma A, Yin M, Al-Harthi L Curr HIV/AIDS Rep. 2022; 19(5):312-327.

PMID: 35726043 PMC: 10309294. DOI: 10.1007/s11904-022-00613-1.

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