The SWAN Song: Study of Women's Health Across the Nation's Recurring Themes

Overview

Journal Obstet Gynecol Clin North Am

Specialty Gynecology & Obstetrics

Date 2011 Oct 4

PMID 21961710

Citations 48

Authors

Nanette Santoro

Kim Sutton-Tyrrell

Affiliations

Soon will be listed here.

Abstract

Reproductive health can be a reflection of overall health. It follows that abnormalities of reproductive milestones may be a manifestation of unhealthy aging. Since 1994, the Study of Women's Health Across the Nation (SWAN) has assessed how menopause and the process of that transition may affect future health. Themes have emerged from SWAN associating patterns of hormones and symptoms with metabolic status.The nature of these relationships vary as women traverse the menopause and ovarian hormone production ceases. This review describes these cross-cutting themes and their possible meaning for the health of the mid-life woman.

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References

Greendale G, Gold E . Lifestyle factors: are they related to vasomotor symptoms and do they modify the effectiveness or side effects of hormone therapy?. Am J Med. 2006; 118 Suppl 12B:148-54. DOI: 10.1016/j.amjmed.2005.09.049. View

Derby C, Wildman R, McGinn A, Green R, Polotsky A, Ram K . Cardiovascular risk factor variation within a Hispanic cohort: SWAN, the Study of Women's Health Across the Nation. Ethn Dis. 2011; 20(4):396-402. PMC: 3059124. View

Green R, Santoro N, McGinn A, Wildman R, Derby C, Polotsky A . The relationship between psychosocial status, acculturation and country of origin in mid-life Hispanic women: data from the Study of Women's Health Across the Nation (SWAN). Climacteric. 2010; 13(6):534-43. PMC: 3677597. DOI: 10.3109/13697131003592713. View

Rocca W, Grossardt B, de Andrade M, Malkasian G, Melton 3rd L . Survival patterns after oophorectomy in premenopausal women: a population-based cohort study. Lancet Oncol. 2006; 7(10):821-8. DOI: 10.1016/S1470-2045(06)70869-5. View

Wildman R, Colvin A, Powell L, Matthews K, Everson-Rose S, Hollenberg S . Associations of endogenous sex hormones with the vasculature in menopausal women: the Study of Women's Health Across the Nation (SWAN). Menopause. 2008; 15(3):414-21. PMC: 2874195. DOI: 10.1097/gme.0b013e318154b6f5. View

Merz C, Johnson B, Sharaf B, Bittner V, Berga S, Braunstein G . Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: a report from the NHLBI-sponsored WISE study. J Am Coll Cardiol. 2003; 41(3):413-9. DOI: 10.1016/s0735-1097(02)02763-8. View

Matthews K, Schott L, Bromberger J, Cyranowski J, Everson-Rose S, Sowers M . Associations between depressive symptoms and inflammatory/hemostatic markers in women during the menopausal transition. Psychosom Med. 2007; 69(2):124-30. DOI: 10.1097/01.psy.0000256574.30389.1b. View

Kok H, van Asselt K, van der Schouw Y, van der Tweel I, Peeters P, Wilson P . Heart disease risk determines menopausal age rather than the reverse. J Am Coll Cardiol. 2006; 47(10):1976-83. DOI: 10.1016/j.jacc.2005.12.066. View

Gold E, Bromberger J, Crawford S, Samuels S, Greendale G, Harlow S . Factors associated with age at natural menopause in a multiethnic sample of midlife women. Am J Epidemiol. 2001; 153(9):865-74. DOI: 10.1093/aje/153.9.865. View

10.

Powell L, Meyer P, Weiss G, Matthews K, Santoro N, Randolph Jr J . Ethnic differences in past hysterectomy for benign conditions. Womens Health Issues. 2005; 15(4):179-86. DOI: 10.1016/j.whi.2005.05.002. View

11.

Torrens J, Sutton-Tyrrell K, Zhao X, Matthews K, Brockwell S, Sowers M . Relative androgen excess during the menopausal transition predicts incident metabolic syndrome in midlife women: study of Women's Health Across the Nation. Menopause. 2008; 16(2):257-64. PMC: 2950016. DOI: 10.1097/gme.0b013e318185e249. View

12.

Kravitz H, Ganz P, Bromberger J, Powell L, Sutton-Tyrrell K, Meyer P . Sleep difficulty in women at midlife: a community survey of sleep and the menopausal transition. Menopause. 2003; 10(1):19-28. DOI: 10.1097/00042192-200310010-00005. View

13.

Gold E, Colvin A, Avis N, Bromberger J, Greendale G, Powell L . Longitudinal analysis of the association between vasomotor symptoms and race/ethnicity across the menopausal transition: study of women's health across the nation. Am J Public Health. 2006; 96(7):1226-35. PMC: 1483882. DOI: 10.2105/AJPH.2005.066936. View

14.

Finkelstein J, Brockwell S, Mehta V, Greendale G, Sowers M, Ettinger B . Bone mineral density changes during the menopause transition in a multiethnic cohort of women. J Clin Endocrinol Metab. 2007; 93(3):861-8. PMC: 2266953. DOI: 10.1210/jc.2007-1876. View

15.

Randolph Jr J, Zheng H, Sowers M, Crandall C, Crawford S, Gold E . Change in follicle-stimulating hormone and estradiol across the menopausal transition: effect of age at the final menstrual period. J Clin Endocrinol Metab. 2010; 96(3):746-54. PMC: 3047231. DOI: 10.1210/jc.2010-1746. View

16.

Schoenbaum E, Hartel D, Lo Y, Howard A, Floris-Moore M, Arnsten J . HIV infection, drug use, and onset of natural menopause. Clin Infect Dis. 2005; 41(10):1517-24. DOI: 10.1086/497270. View

17.

Ossewaarde M, Bots M, Verbeek A, Peeters P, van der Graaf Y, Grobbee D . Age at menopause, cause-specific mortality and total life expectancy. Epidemiology. 2005; 16(4):556-62. DOI: 10.1097/01.ede.0000165392.35273.d4. View

18.

Green R, Polotsky A, Wildman R, McGinn A, Lin J, Derby C . Menopausal symptoms within a Hispanic cohort: SWAN, the Study of Women's Health Across the Nation. Climacteric. 2010; 13(4):376-84. PMC: 3268678. DOI: 10.3109/13697130903528272. View

19.

Luborsky J, Meyer P, Sowers M, Gold E, Santoro N . Premature menopause in a multi-ethnic population study of the menopause transition. Hum Reprod. 2003; 18(1):199-206. DOI: 10.1093/humrep/deg005. View

20.

Gold E, Block G, Crawford S, Lachance L, FitzGerald G, Miracle H . Lifestyle and demographic factors in relation to vasomotor symptoms: baseline results from the Study of Women's Health Across the Nation. Am J Epidemiol. 2004; 159(12):1189-99. DOI: 10.1093/aje/kwh168. View