The Potential Usefulness of Biological Markers in Risk Assessment

Overview

Journal Environ Health Perspect

Date 1987 Dec 1

PMID 3447891

Citations 13

Authors

F Perera

Affiliations

Soon will be listed here.

Abstract

Substantial data have been generated during the last 5 years in experimental systems and human populations which shed light on the potential usefulness of biological markers in human cancer risk assessment. Following a brief review of overall progress to date in the biomonitoring of human populations, this paper turns to the growing body of data regarding carcinogen-DNA and protein adducts as illustrative markers of biologically effective dose of carcinogens. The data base illustrates considerable human inter-individual variation in binding and the presence of significant "background" levels of adducts--both of which support the absence of human population thresholds for exposure to carcinogens. The contribution of adduct data to our understanding of the shape of low dose-response curve and the reliability of inter-species extrapolation, as well as the relevance of adducts to cancer risk, are also discussed. Even though adducts can now be useful in hazard identification or qualitative risk assessment, more research is needed before they can serve as quantitative predictors of human cancer risk.

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References

EHRENBERG L, Hiesche K, Wenneberg I . Evaluation of genetic risks of alkylating agents: tissue doses in the mouse from air contaminated with ethylene oxide. Mutat Res. 1974; 24(2):83-103. DOI: 10.1016/0027-5107(74)90123-7. View

Calleman C, EHRENBERG L, Jansson B, Segerback D, Svensson K, WACHTMEISTER C . Monitoring and risk assessment by means of alkyl groups in hemoglobin in persons occupationally exposed to ethylene oxide. J Environ Pathol Toxicol. 1978; 2(2):427-42. View

Lutz W . In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis. Mutat Res. 1979; 65(4):289-356. DOI: 10.1016/0165-1110(79)90006-x. View

Pegg A, Perry W . Alkylation of nucleic acids and metabolism of small doses of dimethylnitrosamine in the rat. Cancer Res. 1981; 41(8):3128-32. View

Perera F, Weinstein I . Molecular epidemiology and carcinogen-DNA adduct detection: new approaches to studies of human cancer causation. J Chronic Dis. 1982; 35(7):581-600. DOI: 10.1016/0021-9681(82)90078-9. View

Dunn B . Wide-range linear dose-response curve for DNA binding of orally administered benzo(a)pyrene in mice. Cancer Res. 1983; 43(6):2654-8. View

Hennings H, Shores R, Wenk M, Spangler E, Tarone R, Yuspa S . Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters. Nature. 1983; 304(5921):67-9. DOI: 10.1038/304067a0. View

Bartsch H, Terracini B, Malaveille C, Tomatis L, Wahrendorf J, Brun G . Quantitative comparison of carcinogenicity, mutagenicity and electrophilicity of 10 direct-acting alkylating agents and of the initial O6:7-alkylguanine ratio in DNA with carcinogenic potency in rodents. Mutat Res. 1983; 110(2):181-219. DOI: 10.1016/0027-5107(83)90140-9. View

Murthy M, Calleman C, Segerback D, Svensson K . Relationships between ethylation of hemoglobin, ethylation of DNA and administered amount of ethyl methanesulfonate in the mouse. Mutat Res. 1984; 127(1):1-8. DOI: 10.1016/0027-5107(84)90133-7. View

10.

Starr T, Heck H . Differentiation between metabolic incorporation and covalent binding in the labeling of macromolecules in the rat nasal mucosa and bone marrow by inhaled [14C]- and [3H]formaldehyde. Toxicol Appl Pharmacol. 1984; 76(1):26-44. DOI: 10.1016/0041-008x(84)90026-7. View

11.

Starr T, Buck R . The importance of delivered dose in estimating low-dose cancer risk from inhalation exposure to formaldehyde. Fundam Appl Toxicol. 1984; 4(5):740-53. DOI: 10.1016/0272-0590(84)90095-2. View

12.

Reddy M, Irvin T, Randerath K . Formation and persistence of sterigmatocystin--DNA adducts in rat liver determined via 32P-postlabeling analysis. Mutat Res. 1985; 152(1):85-96. View

13.

Umbenhauer D, Wild C, Montesano R, Saffhill R, Boyle J, Huh N . O(6)-methyldeoxyguanosine in oesophageal DNA among individuals at high risk of oesophageal cancer. Int J Cancer. 1985; 36(6):661-5. DOI: 10.1002/ijc.2910360607. View

14.

Belinsky S, White C, Boucheron J, Richardson F, Swenberg J, Anderson M . Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res. 1986; 46(3):1280-4. View

15.

Harris C . Future directions in the use of DNA adducts as internal dosimeters for monitoring human exposure to environmental mutagens and carcinogens. Environ Health Perspect. 1985; 62:185-91. PMC: 1568664. DOI: 10.1289/ehp.8562185. View

16.

Wogan G, Gorelick N . Chemical and biochemical dosimetry of exposure to genotoxic chemicals. Environ Health Perspect. 1985; 62:5-18. PMC: 1568678. DOI: 10.1289/ehp.85625. View

17.

Reed E, Yuspa S, Zwelling L, Ozols R, Poirier M . Quantitation of cis-diamminedichloroplatinum II (cisplatin)-DNA-intrastrand adducts in testicular and ovarian cancer patients receiving cisplatin chemotherapy. J Clin Invest. 1986; 77(2):545-50. PMC: 423377. DOI: 10.1172/JCI112335. View

18.

Hogstedt C . Future perspectives, needs and expectations of biological monitoring of exposure to genotoxicants in prevention of occupational disease. Prog Clin Biol Res. 1986; 207:231-43. View

19.

Phillips D, Hewer A, Grover P . Aromatic DNA adducts in human bone marrow and peripheral blood leukocytes. Carcinogenesis. 1986; 7(12):2071-5. DOI: 10.1093/carcin/7.12.2071. View

20.

Bryant M, Skipper P, Tannenbaum S, Maclure M . Hemoglobin adducts of 4-aminobiphenyl in smokers and nonsmokers. Cancer Res. 1987; 47(2):602-8. View