Retrospective Study of Aldosterone and Progesterone Secreting Adrenal Tumors in 10 Cats

Overview

Journal J Vet Intern Med

Specialties General Medicine
Veterinary Medicine

Date 2021 Sep 2

PMID 34473866

Citations 5

Authors

Cailin C Harro

Kent R Refsal

Nicole Shaw

Samantha M Alston

William Folger

Carolyn Gross

W Mark Cousins

Colleen F Monahan

Michal Mazaki-Tovi

Daniel K Langlois

Affiliations

Soon will be listed here.

Abstract

Background: Primary hyperaldosteronism caused by adrenal neoplasia has been well described in cats. Multiple corticosteroid abnormalities occur in a subset of affected cats, but characterizations of this syndrome are limited to several case reports.

Objectives: To describe a series of cats with adrenal tumors secreting aldosterone and additional corticosteroids.

Animals: Ten cats with multiple corticosteroid secreting adrenocortical tumors.

Methods: Retrospective case series. Medical records of cats with adrenal tumors secreting both aldosterone and progesterone were identified. Data concerning historical findings, clinicopathologic features, treatments, and outcomes were retrieved from medical records.

Results: All 10 cats had diabetes mellitus in addition to biochemical features of hyperaldosteronism such as hypokalemia. High corticosterone concentrations were observed in all 3 cats in which this corticosteroid was measured. Ultrasound examinations revealed unilateral adrenal tumors in all 10 cases, and the contralateral adrenal gland was either atrophied or not identified in 5 cats. Three of 4 cats developed hypoadrenocorticism after surgical adrenalectomy. Three cats achieved diabetic remission after adrenalectomy. Two cats treated with adrenalectomy survived >1 year, 1 cat survived 6.5 months, and 1 cat was alive 5.5 months after diagnosis. Survival >1 year occurred in 2 of 4 cats treated with medical management alone. Two cats were not treated.

Conclusions And Clinical Importance: The presence of multiple corticosteroid abnormalities should be considered in cats with aldosterone secreting adrenal tumors, especially those with concurrent diabetes mellitus. Both surgical and medical management can result in long-term survival, although diabetic remission was documented only in cats undergoing adrenalectomy.

Citing Articles

Long-lasting hypoaldosteronism after adrenalectomy in a cat with hyperaldosteronism.

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PMID: 38746623 PMC: 11092530. DOI: 10.1177/20551169241243012.

Case report: Androgen-secreting adrenocortical tumors in eight cats.

Erger C, Gerras A, Conley A, Gilor C, DeMarle K, Refsal K Front Vet Sci. 2023; 10:1158142.

PMID: 37383353 PMC: 10293747. DOI: 10.3389/fvets.2023.1158142.

Prevalence of hypersomatotropism and hyperthyroidism in cats with diabetes mellitus from referral centers in Buenos Aires (2020-2022).

Miceli D, Garcia J, Rey Amunategui J, Pompili G, Rial L, Mas J J Feline Med Surg. 2023; 25(2):1098612X221148565.

PMID: 36779783 PMC: 10812081. DOI: 10.1177/1098612X221148565.

Surgical findings and outcomes after unilateral adrenalectomy for primary hyperaldosteronism in cats: a multi-institutional retrospective study.

Magno S, Foglia A, Rossanese M, Montinaro V, Cola V, Pisoni L J Feline Med Surg. 2023; 25(1):1098612X221135124.

PMID: 36706013 PMC: 10812040. DOI: 10.1177/1098612X221135124.

Retrospective study of aldosterone and progesterone secreting adrenal tumors in 10 cats.

Harro C, Refsal K, Shaw N, Alston S, Folger W, Gross C J Vet Intern Med. 2021; 35(5):2159-2166.

PMID: 34473866 PMC: 8478046. DOI: 10.1111/jvim.16256.

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