Co-ordination of Brain and Heart Oscillations During Non-rapid Eye Movement Sleep

Overview

Journal J Sleep Res

Specialty Psychiatry

Date 2021 Sep 1

PMID 34467582

Citations 4

Authors

Christian Mikutta

Marion Wenke

Kai Spiegelhalder

Elisabeth Hertenstein

Jonathan G Maier

Carlotta L Schneider

Kristoffer Feher

Julian Koenig

Andreas Altorfer

Dieter Riemann

Christoph Nissen

Bernd Feige

Affiliations

Soon will be listed here.

Abstract

Oscillatory activities of the brain and heart show a strong variation across wakefulness and sleep. Separate lines of research indicate that non-rapid eye movement (NREM) sleep is characterised by electroencephalographic slow oscillations (SO), sleep spindles, and phase-amplitude coupling of these oscillations (SO-spindle coupling), as well as an increase in high-frequency heart rate variability (HF-HRV), reflecting enhanced parasympathetic activity. The present study aimed to investigate further the potential coordination between brain and heart oscillations during NREM sleep. Data were derived from one sleep laboratory night with polysomnographic monitoring in 45 healthy participants (22 male, 23 female; mean age 37 years). The associations between the strength (modulation index [MI]) and phase direction of SO-spindle coupling (circular measure) and HF-HRV during NREM sleep were investigated using linear modelling. First, a significant SO-spindle coupling (MI) was observed for all participants during NREM sleep, with spindle peaks preferentially occurring during the SO upstate (phase direction). Second, linear model analyses of NREM sleep showed a significant relationship between the MI and HF-HRV (F = 20.1, r = 0.30, p < 0.001) and a tentative circular-linear correlation between phase direction and HF-HRV (F = 3.07, r = 0.12, p = 0.056). We demonstrated a co-ordination between SO-spindle phase-amplitude coupling and HF-HRV during NREM sleep, presumably related to parallel central nervous and peripheral vegetative arousal systems regulation. Further investigating the fine-graded co-ordination of brain and heart oscillations might improve our understanding of the links between sleep and cardiovascular health.

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Co-ordination of brain and heart oscillations during non-rapid eye movement sleep.

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