Synthetic Hyperacetylation of Nucleosomal Histones

Overview

Journal RSC Chem Biol

Publisher Royal Society of Chemistry

Specialty Biology

Date 2021 Aug 30

PMID 34458748

Citations 5

Authors

Hidetoshi Kajino

Tomomi Nagatani

Miku Oi

Tomoya Kujirai

Hitoshi Kurumizaka

Atsuya Nishiyama

Makoto Nakanishi

Kenzo Yamatsugu

Shigehiro A Kawashima

Motomu Kanai

Affiliations

Soon will be listed here.

Abstract

We report combinations of a DMAP-based catalyst and phenyl acetate with optimal electron density as a new chemical system for high-yield, selective synthetic acetylation of histone lysine residues. The utility of this chemical system as a unique biologic tool is demonstrated by applying it to sperm chromatin.

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A chemical catalyst enabling histone acylation with endogenous acyl-CoA.

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Live Cell Synthetic Histone Acetylation by Chemical Catalyst.

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Site-Specific Labeling of Endogenous Proteins Using CoLDR Chemistry.

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Live-cell epigenome manipulation by synthetic histone acetylation catalyst system.

Fujiwara Y, Yamanashi Y, Fujimura A, Sato Y, Kujirai T, Kurumizaka H Proc Natl Acad Sci U S A. 2021; 118(4).

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