Modification of Proteins Using Olefin Metathesis

Overview

Journal Mater Chem Front

Publisher Royal Society of Chemistry

Date 2021 Aug 30

PMID 34457313

Citations 14

Authors

Marco S Messina

Heather D Maynard

Affiliations

Soon will be listed here.

Abstract

Olefin metathesis has revolutionized synthetic approaches to carbon-carbon bond formation. With a rich history beginning in industrial settings through its advancement in academic laboratories leading to new and highly active metathesis catalysts, olefin metathesis has found use in the generation of complex natural products, the cyclization of bioactive materials, and in the polymerization of new and unique polymer architectures. Throughout this review, we will trace the deployment of olefin metathesis-based strategies for the modification of proteins, a process which has been facilitated by the extensive development of stable, isolable, and highly active transition-metal-based metathesis catalysts. We first begin by summarizing early works which detail peptide modification strategies that played a vital role in identifying stable metathesis catalysts. We then delve into protein modification using cross metathesis and finish with recent work on the generation of protein-polymer conjugates through ring-opening metathesis polymerization.

Citing Articles

Anionic Olefin Metathesis Catalysts Enable Modification of Unprotected Biomolecules in Water.

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Biocompatible strategies for peptide macrocyclisation.

He J, Ghosh P, Nitsche C Chem Sci. 2024; 15(7):2300-2322.

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Modular and diverse synthesis of amino acids via asymmetric decarboxylative protonation of aminomalonic acids.

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Influence of Substituents in a Six-Membered Chelate Ring of HG-Type Complexes Containing an N→Ru Bond on Their Stability and Catalytic Activity.

Vasilyev K, Antonova A, Volchkov N, Logvinenko N, Nikitina E, Grigoriev M Molecules. 2023; 28(3).

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Water-Accelerated Decomposition of Olefin Metathesis Catalysts.

Blanco C, Fogg D ACS Catal. 2023; 13(2):1097-1102.

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