Update in Diagnostics of Toscana Virus Infection in a Hyperendemic Region (Southern Spain)

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2021 Aug 28

PMID 34452304

Citations 5

Authors

Sara Sanbonmatsu-Gamez

Irene Pedrosa-Corral

Jose Maria Navarro-Mari

Mercedes Perez-Ruiz

Affiliations

Soon will be listed here.

Abstract

The sandfly fever Toscana virus (TOSV, genus , family ) is endemic in Mediterranean countries. In Spain, phylogenetic studies of TOSV strains demonstrated that a genotype, different from the Italian, was circulating. This update reports 107 cases of TOSV neurological infection detected in Andalusia from 1988 to 2020, by viral culture, serology and/or RT-PCR. Most cases were located in Granada province, a hyperendemic region. TOSV neurological infection may be underdiagnosed since few laboratories include this virus in their portfolio. This work presents a reliable automated method, validated for the detection of the main viruses involved in acute meningitis and encephalitis, including the arboviruses TOSV and West Nile virus. This assay solves the need for multiple molecular platforms for different viruses and thus, improves the time to results for these syndromes, which require a rapid and efficient diagnostic approach.

Citing Articles

Comprehensive evaluation of nucleic acid amplification methods widely used for generic detection of sandfly-borne phleboviruses.

Polat C, Ayhan N, Ergunay K, Charrel R Microbiol Spectr. 2024; 12(4):e0342823.

PMID: 38456695 PMC: 10986501. DOI: 10.1128/spectrum.03428-23.

Untargeted metagenomic sequencing identifies Toscana virus in patients with idiopathic meningitis, southern Spain, 2015 to 2019.

Gambaro F, Perez A, Prot M, Aguera E, Baidaliuk A, Sanchez-Seco M Euro Surveill. 2023; 28(45).

PMID: 37943504 PMC: 10636744. DOI: 10.2807/1560-7917.ES.2023.28.45.2200913.

Progress in etiological diagnosis of viral meningitis.

Xu H, Chen P, Guo S, Shen X, Lu Y Front Neurol. 2023; 14:1193834.

PMID: 37583954 PMC: 10423822. DOI: 10.3389/fneur.2023.1193834.

Epidemiology, Isolation, and Genetic Characterization of Toscana Virus in Algerian Patients Displaying Neurological Infection, 2016-2018.

Benbetka C, Hachid A, Benallal K, Khardine F, Ayhan N, Bouredjoul N IJID Reg. 2023; 7:193-198.

PMID: 37123383 PMC: 10131063. DOI: 10.1016/j.ijregi.2023.03.012.

Sandfly-Borne Phleboviruses in Portugal: Four and Still Counting.

Amaro F, Ze-Ze L, Alves M Viruses. 2022; 14(8).

PMID: 36016390 PMC: 9413822. DOI: 10.3390/v14081768.

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