When Cyclodextrins Met Data Science: Unveiling Their Pharmaceutical Applications Through Network Science and Text-Mining

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2021 Aug 28

PMID 34452258

Citations 8

Authors

Juliana Rincon-Lopez

Yara C Almanza-Arjona

Alejandro P Riascos

Yareli Rojas-Aguirre

Affiliations

Soon will be listed here.

Abstract

We present a data-driven approach to unveil the pharmaceutical technologies of cyclodextrins (CDs) by analyzing a dataset of CD pharmaceutical patents. First, we implemented network science techniques to represent CD patents as a single structure and provide a framework for unsupervised detection of keywords in the patent dataset. Guided by those keywords, we further mined the dataset to examine the patenting trends according to CD-based dosage forms. CD patents formed complex networks, evidencing the supremacy of CDs for solubility enhancement and how this has triggered cutting-edge applications based on or beyond the solubility improvement. The networks exposed the significance of CDs to formulate aqueous solutions, tablets, and powders. Additionally, they highlighted the role of CDs in formulations of anti-inflammatory drugs, cancer therapies, and antiviral strategies. Text-mining showed that the trends in CDs for aqueous solutions, tablets, and powders are going upward. Gels seem to be promising, while patches and fibers are emerging. Cyclodextrins' potential in suspensions and emulsions is yet to be recognized and can become an opportunity area. This is the first unsupervised/supervised data-mining approach aimed at depicting a landscape of CDs to identify trending and emerging technologies and uncover opportunity areas in CD pharmaceutical research.

Citing Articles

A Review of Machine Learning and QSAR/QSPR Predictions for Complexes of Organic Molecules with Cyclodextrins.

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Machine learning approaches for biomolecular, biophysical, and biomaterials research.

Rickert C, Lieleg O Biophys Rev (Melville). 2024; 3(2):021306.

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Change in the Kinetic Regime of Aggregation of Yeast Alcohol Dehydrogenase in the Presence of 2-Hydroxypropyl-β-cyclodextrin.

Borzova V, Chernikov A, Mikhaylova V, Kurganov B Int J Mol Sci. 2023; 24(22).

PMID: 38003330 PMC: 10671268. DOI: 10.3390/ijms242216140.

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives.

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