Cyclodextrins in Antiviral Therapeutics and Vaccines

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2021 Apr 3

PMID 33808834

Citations 19

Authors

Susana Santos Braga

Jessica S Barbosa

Nadia E Santos

Firas El-Saleh

Filipe A Almeida Paz

Affiliations

Soon will be listed here.

Abstract

The present review describes the various roles of cyclodextrins (CDs) in vaccines against viruses and in antiviral therapeutics. The first section describes the most commonly studied application of cyclodextrins-solubilisation and stabilisation of antiviral drugs; some examples also refer to their beneficial taste-masking activity. The second part of the review describes the role of cyclodextrins in antiviral vaccine development and stabilisation, where they are employed as adjuvants and cryopreserving agents. In addition, cyclodextrin-based polymers as delivery systems for mRNA are currently under development. Lastly, the use of cyclodextrins as pharmaceutical active ingredients for the treatment of viral infections is explored. This new field of application is still taking its first steps. Nevertheless, promising results from the use of cyclodextrins as agents to treat other pathologies are encouraging. We present potential applications of the results reported in the literature and highlight the products that are already available on the market.

Citing Articles

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A Review of Machine Learning and QSAR/QSPR Predictions for Complexes of Organic Molecules with Cyclodextrins.

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Phenolic Acid-β-Cyclodextrin Complexation Study to Mask Bitterness in Wheat Bran: A Machine Learning-Based QSAR Study.

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Cyclodextrins and their potential applications for delivering vitamins, iron, and iodine for improving micronutrient status.

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