Serum 25-Hydroxyvitamin D Concentrations and Atopic Dermatitis in Early Childhood: Findings from the Japan Environment and Children's Study

Overview

Journal Nutrients

Date 2021 Aug 27

PMID 34444921

Citations 4

Authors

Limin Yang

Miori Sato

Mayako Saito-Abe

Minaho Nishizato

Hidetoshi Mezawa

Kiwako Yamamoto-Hanada

Yukihiro Ohya

The Japan Environment And Childrens Study Jecs Group

Affiliations

Soon will be listed here.

Abstract

Vitamin D (VitD) may affect immune system modulation and result in the development of atopic dermatitis (AD). However, published findings have remained controversial. We investigated the association between early-life 25-hydroxyvitamin D (25(OH)D) levels and AD risk at childhood with a birth cohort. The data were obtained from "the Japan Environment and Children's Study (JECS)" and "the Sub-Cohort study of JECS" performed with children aged 2 years. "Liquid chromatography-tandem mass spectrometry" was used to measure VitD. The information on AD was obtained from parents' answers to a questionnaire when their children were aged 3 years. In order to explain the seasonal effects on VitD levels, a deseasonalized continuous variable was further calculated. The logistic regression models were fitted to evaluate the effect of VitD on childhood AD. The study included 4378 children with complete data on VitD and AD. The results from models indicated that low VitD at 2 years was not a risk factor for the development of AD at 3 years, after adjusting for potential confounders. Moreover, there was no U-shape relationship between deseasonalized VitD and childhood AD. Overall, early-life 25(OH)D levels were not link to the increased risk of developing childhood AD.

Citing Articles

Vitamin D and allergic diseases.

Zhang P, Xu Q, Zhu R Front Immunol. 2024; 15:1420883.

PMID: 39026686 PMC: 11254667. DOI: 10.3389/fimmu.2024.1420883.

Causal Associations between Vitamin D Levels and Psoriasis, Atopic Dermatitis, and Vitiligo: A Bidirectional Two-Sample Mendelian Randomization Analysis.

Ren Y, Liu J, Li W, Zheng H, Dai H, Qiu G Nutrients. 2022; 14(24).

PMID: 36558443 PMC: 9785064. DOI: 10.3390/nu14245284.

Smoking Exposure Is Associated with Serum Vitamin D Deficiency in Children: Evidence from the Japan Environment and Children's Study.

Yang L, Sato M, Saito-Abe M, Miyaji Y, Sato C, Nishizato M Nutrients. 2022; 14(15).

PMID: 35956297 PMC: 9370804. DOI: 10.3390/nu14153121.

An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study.

Afghani J, Traidl-Hoffmann C, Schmitt-Kopplin P, Reiger M, Mueller C Int J Mol Sci. 2022; 23(15).

PMID: 35955924 PMC: 9368995. DOI: 10.3390/ijms23158791.

References

Muehleisen B, Gallo R . Vitamin D in allergic disease: shedding light on a complex problem. J Allergy Clin Immunol. 2013; 131(2):324-9. DOI: 10.1016/j.jaci.2012.12.1562. View

Yamamoto-Hanada K, Pak K, Saito-Abe M, Yang L, Sato M, Irahara M . Allergy and immunology in young children of Japan: The JECS cohort. World Allergy Organ J. 2020; 13(11):100479. PMC: 7652713. DOI: 10.1016/j.waojou.2020.100479. View

Braegger C, Campoy C, Colomb V, Decsi T, Domellof M, Fewtrell M . Vitamin D in the healthy European paediatric population. J Pediatr Gastroenterol Nutr. 2013; 56(6):692-701. DOI: 10.1097/MPG.0b013e31828f3c05. View

Cairncross C, Grant C, Stonehouse W, Conlon C, McDonald B, Houghton L . The Relationship between Vitamin D Status and Allergic Diseases in New Zealand Preschool Children. Nutrients. 2016; 8(6). PMC: 4924167. DOI: 10.3390/nu8060326. View

Ellwood P, Asher M, Beasley R, Clayton T, Stewart A . The international study of asthma and allergies in childhood (ISAAC): phase three rationale and methods. Int J Tuberc Lung Dis. 2005; 9(1):10-6. View

Asher M, Keil U, Anderson H, Beasley R, Crane J, Martinez F . International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J. 1995; 8(3):483-91. DOI: 10.1183/09031936.95.08030483. View

DeLuca H, Schnoes H . Vitamin D: recent advances. Annu Rev Biochem. 1983; 52:411-39. DOI: 10.1146/annurev.bi.52.070183.002211. View

Reinehr T, Langrock C, Hamelmann E, Lucke T, Koerner-Rettberg C, Holtmann M . 25-Hydroxvitamin D concentrations are not lower in children with bronchial asthma, atopic dermatitis, obesity, or attention-deficient/hyperactivity disorder than in healthy children. Nutr Res. 2018; 52:39-47. DOI: 10.1016/j.nutres.2018.01.002. View

Boyle V, Thorstensen E, Thompson J, McCowan L, Mitchell E, Godfrey K . The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study. Int J Obes (Lond). 2017; 41(12):1755-1760. DOI: 10.1038/ijo.2017.182. View

10.

Yamamoto-Hanada K, Yang L, Saito-Abe M, Sato M, Inuzuka Y, Toyokuni K . Four phenotypes of atopic dermatitis in Japanese children: A general population birth cohort study. Allergol Int. 2019; 68(4):521-523. DOI: 10.1016/j.alit.2019.02.010. View

11.

Sekiyama M, Yamazaki S, Michikawa T, Nakayama S, Nitta H, Taniguchi Y . Study Design and Participants' Profile in the Sub-Cohort Study in the Japan Environment and Children's Study (JECS). J Epidemiol. 2021; 32(5):228-236. PMC: 8979916. DOI: 10.2188/jea.JE20200448. View

12.

Avena-Woods C . Overview of atopic dermatitis. Am J Manag Care. 2017; 23(8 Suppl):S115-S123. View

13.

Sanmartin R, Pardos C, Doste D, Aguilera J, Alijarde R, Jesus Agon-Banzo P . The association between atopic dermatitis and serum 25-hydroxyvitamin D in children: Influence of sun exposure, diet, and atopy features-A cross-sectional study. Pediatr Dermatol. 2020; 37(2):294-300. DOI: 10.1111/pde.14049. View

14.

Yang L, Sato M, Saito-Abe M, Irahara M, Nishizato M, Sasaki H . Association of Hemoglobin and Hematocrit Levels during Pregnancy and Maternal Dietary Iron Intake with Allergic Diseases in Children: The Japan Environment and Children's Study (JECS). Nutrients. 2021; 13(3). PMC: 7999127. DOI: 10.3390/nu13030810. View

15.

Wills A, Shaheen S, Granell R, Henderson A, Fraser W, Lawlor D . Maternal 25-hydroxyvitamin D and its association with childhood atopic outcomes and lung function. Clin Exp Allergy. 2013; 43(10):1180-8. PMC: 3814422. DOI: 10.1111/cea.12172. View

16.

Weiland S, Bjorksten B, Brunekreef B, Cookson W, von Mutius E, Strachan D . Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC II): rationale and methods. Eur Respir J. 2004; 24(3):406-12. DOI: 10.1183/09031936.04.00090303. View

17.

Bikle D . Vitamin D metabolism and function in the skin. Mol Cell Endocrinol. 2011; 347(1-2):80-9. PMC: 3188673. DOI: 10.1016/j.mce.2011.05.017. View

18.

Hattori H, Kitamura A, Takahashi F, Kobayashi N, Sato A, Miyauchi N . The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children's Study. Reprod Biol Endocrinol. 2019; 17(1):27. PMC: 6387559. DOI: 10.1186/s12958-019-0471-1. View

19.

Komori K, Komori M, Eitoku M, Muchanga S, Ninomiya H, Kobayashi T . Verbal abuse during pregnancy increases frequency of newborn hearing screening referral: The Japan Environment and Children's Study. Child Abuse Negl. 2019; 90:193-201. DOI: 10.1016/j.chiabu.2019.01.025. View

20.

Oren E, Banerji A, Camargo Jr C . Vitamin D and atopic disorders in an obese population screened for vitamin D deficiency. J Allergy Clin Immunol. 2008; 121(2):533-4. DOI: 10.1016/j.jaci.2007.11.005. View