The Relationship Between Vitamin D Status and Allergic Diseases in New Zealand Preschool Children

Overview

Journal Nutrients

Date 2016 Jun 4

PMID 27258306

Citations 9

Authors

Carolyn Cairncross

Cameron Grant

Welma Stonehouse

Cath Conlon

Barry McDonald

Lisa Houghton

Darryl Eyles

Carlos A Camargo

Jane Coad

Pamela von Hurst

Affiliations

Soon will be listed here.

Abstract

Recent research on vitamin D in young children has expanded from bone development to exploring immunomodulatory effects. Our aim was to investigate the relationship of vitamin D status and allergic diseases in preschool-aged children in New Zealand. Dried capillary blood spots were collected from 1329 children during late-winter to early-spring for 25(OH)D measurement by LC-MS/MS. Caregivers completed a questionnaire about their child's recent medical history. Analysis was by multivariable logistic regression. Mean 25(OH)D concentration was 52(SD19) nmol/L, with 7% of children <25 nmol/L and 49% <50 nmol/L. Children with 25(OH)D concentrations ≥75 nmol/L (n = 29) had a two-fold increased risk for parent-report of doctor-diagnosed food allergy compared to children with 25(OH)D 50-74.9 nmol/L (OR = 2.21, 1.33-3.68, p = 0.002). No associations were present between 25(OH)D concentration and presence of parent-reported eczema, allergic rhinoconjunctivitis or atopic asthma. Vitamin D deficiency was not associated with several allergic diseases in these New Zealand preschool children. In contrast, high 25(OH)D concentrations were associated with a two-fold increased risk of parental-report food allergy. This increase supports further research into the association between vitamin D status and allergic disease in preschool children.

Citing Articles

Serum vitamin D status in a cohort of infants with food protein‑induced gastrointestinal disease.

Zhou M, Li X, Yang J, Xiong L, He X, Xie X Biomed Rep. 2023; 19(4):71.

PMID: 37719677 PMC: 10502572. DOI: 10.3892/br.2023.1653.

Vitamin D, cytokine profiles, and disease severity in infants with atopic dermatitis: a single centre, cross-sectional study.

Barlianto W, Wulandari D, Sari T, Firdayanti V, Avandi M Postepy Dermatol Alergol. 2022; 39(4):793-799.

PMID: 36090733 PMC: 9454358. DOI: 10.5114/ada.2022.118923.

Mast Cells and Vitamin D Status: A Clinical and Biological Link in the Onset of Allergy and Bone Diseases.

Murdaca G, Allegra A, Tonacci A, Musolino C, Ricciardi L, Gangemi S Biomedicines. 2022; 10(8).

PMID: 36009422 PMC: 9405764. DOI: 10.3390/biomedicines10081877.

Pre- and Postnatal Vitamin D Status and Allergy Outcomes in Early Childhood.

Rueter K, Siafarikas A, Palmer D, Prescott S Biomedicines. 2022; 10(5).

PMID: 35625670 PMC: 9139153. DOI: 10.3390/biomedicines10050933.

A narrative review of vitamin D and food allergy in infants and children.

Di T, Chen L Transl Pediatr. 2021; 10(10):2614-2620.

PMID: 34765485 PMC: 8578786. DOI: 10.21037/tp-21-396.

References

Kerley C, Hutchinson K, Cormican L, Faul J, Greally P, Coghlan D . Vitamin D3 for uncontrolled childhood asthma: A pilot study. Pediatr Allergy Immunol. 2016; 27(4):404-12. DOI: 10.1111/pai.12547. View

Oren E, Banerji A, Camargo Jr C . Vitamin D and atopic disorders in an obese population screened for vitamin D deficiency. J Allergy Clin Immunol. 2008; 121(2):533-4. DOI: 10.1016/j.jaci.2007.11.005. View

Hammar K, Hedlin G, Konradsen J, Nordlund B, Kull I, Giske C . Subnormal levels of vitamin D are associated with acute wheeze in young children. Acta Paediatr. 2014; 103(8):856-61. DOI: 10.1111/apa.12666. View

Liu P, Stenger S, Tang D, Modlin R . Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol. 2007; 179(4):2060-3. DOI: 10.4049/jimmunol.179.4.2060. View

Adorini L, Penna G, Giarratana N, Uskokovic M . Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases. J Cell Biochem. 2003; 88(2):227-33. DOI: 10.1002/jcb.10340. View

Newman M, Brandon T, Groves M, Gregory W, Kapur S, Zava D . A liquid chromatography/tandem mass spectrometry method for determination of 25-hydroxy vitamin D2 and 25-hydroxy vitamin D3 in dried blood spots: a potential adjunct to diabetes and cardiometabolic risk screening. J Diabetes Sci Technol. 2010; 3(1):156-62. PMC: 2769851. DOI: 10.1177/193229680900300118. View

Rothers J, Wright A, Stern D, Halonen M, Camargo Jr C . Cord blood 25-hydroxyvitamin D levels are associated with aeroallergen sensitization in children from Tucson, Arizona. J Allergy Clin Immunol. 2011; 128(5):1093-9.e1-5. PMC: 3205280. DOI: 10.1016/j.jaci.2011.07.015. View

Marklund B, Ahlstedt S, Nordstrom G . Health-related quality of life in food hypersensitive schoolchildren and their families: parents' perceptions. Health Qual Life Outcomes. 2006; 4:48. PMC: 1564003. DOI: 10.1186/1477-7525-4-48. View

Nanzer A, Chambers E, Ryanna K, Richards D, Black C, Timms P . Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion. J Allergy Clin Immunol. 2013; 132(2):297-304.e3. DOI: 10.1016/j.jaci.2013.03.037. View

10.

Eyles D, Anderson C, Ko P, Jones A, Thomas A, Burne T . A sensitive LC/MS/MS assay of 25OH vitamin D3 and 25OH vitamin D2 in dried blood spots. Clin Chim Acta. 2009; 403(1-2):145-51. DOI: 10.1016/j.cca.2009.02.005. View

11.

Kong J, Zhang Z, Musch M, Ning G, Sun J, Hart J . Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol. 2007; 294(1):G208-16. DOI: 10.1152/ajpgi.00398.2007. View

12.

Menon J, Maranda L, Nwosu B . Serum 25-hydroxyvitamin D levels do not correlate with asthma severity in a case-controlled study of children and adolescents. J Pediatr Endocrinol Metab. 2012; 25(7-8):673-9. DOI: 10.1515/jpem-2012-0143. View

13.

Liew W, Williamson E, Tang M . Anaphylaxis fatalities and admissions in Australia. J Allergy Clin Immunol. 2009; 123(2):434-42. DOI: 10.1016/j.jaci.2008.10.049. View

14.

Cheng H, Kim S, Park G, Chang S, Bang S, Won C . Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population. J Allergy Clin Immunol. 2014; 133(4):1048-55. DOI: 10.1016/j.jaci.2013.10.055. View

15.

Allen K, Koplin J, Ponsonby A, Gurrin L, Wake M, Vuillermin P . Vitamin D insufficiency is associated with challenge-proven food allergy in infants. J Allergy Clin Immunol. 2013; 131(4):1109-16, 1116.e1-6. DOI: 10.1016/j.jaci.2013.01.017. View

16.

Ismail A, Aly S, Fayed H, Ahmed S . Serum 25-hydroxyvitamin D and CD4+CD25(+high) FoxP3+ Regulatory T cell as Predictors of Severity of Bronchial Asthma in Children. Egypt J Immunol. 2015; 22(1):9-18. View

17.

Mathieu C, Adorini L . The coming of age of 1,25-dihydroxyvitamin D(3) analogs as immunomodulatory agents. Trends Mol Med. 2002; 8(4):174-9. DOI: 10.1016/s1471-4914(02)02294-3. View

18.

Arshi S, Ghalehbaghi B, Kamrava S, Aminlou M . Vitamin D serum levels in allergic rhinitis: any difference from normal population?. Asia Pac Allergy. 2012; 2(1):45-8. PMC: 3269601. DOI: 10.5415/apallergy.2012.2.1.45. View

19.

Heath A, Williamson E, Ebeling P, Kvaskoff D, Eyles D, English D . Measurements of 25-hydroxyvitamin D concentrations in archived dried blood spots are reliable and accurately reflect those in plasma. J Clin Endocrinol Metab. 2014; 99(9):3319-24. DOI: 10.1210/jc.2014-1269. View

20.

Wang S, Hon K, Kong A, Pong H, Wong G, Leung T . Vitamin D deficiency is associated with diagnosis and severity of childhood atopic dermatitis. Pediatr Allergy Immunol. 2014; 25(1):30-5. DOI: 10.1111/pai.12167. View