Expanding the Myxochelin Natural Product Family by Nicotinic Acid Containing Congeners

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2021 Aug 27

PMID 34443518

Citations 2

Authors

Nicolas A Frank

Mario Szeles

Sergi H Akone

Sari Rasheed

Stephan Huttel

Simon Frewert

Mostafa M Hamed

Jennifer Herrmann

Soren M M Schuler

Anna K H Hirsch

Rolf Muller

Affiliations

Soon will be listed here.

Abstract

Myxobacteria represent a viable source of chemically diverse and biologically active secondary metabolites. The myxochelins are a well-studied family of catecholate-type siderophores produced by various myxobacterial strains. Here, we report the discovery, isolation, and structure elucidation of three new myxochelins N1-N3 from the terrestrial myxobacterium sp. MCy9049, featuring an unusual nicotinic acid moiety. Precursor-directed biosynthesis (PDB) experiments and total synthesis were performed in order to confirm structures, improve access to pure compounds for bioactivity testing, and to devise a biosynthesis proposal. The combined evaluation of metabolome and genome data covering myxobacteria supports the notion that the new myxochelin congeners reported here are in fact frequent side products of the known myxochelin A biosynthetic pathway in myxobacteria.

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