Chronic Kidney Disease-Associated Pruritus

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2021 Aug 26

PMID 34437400

Citations 24

Authors

Puneet Agarwal

Vinita Garg

Priyanka Karagaiah

Jacek C Szepietowski

Stephan Grabbe

Mohamad Goldust

Affiliations

Soon will be listed here.

Abstract

Pruritus is a distressing condition associated with end-stage renal disease (ESRD), advanced chronic kidney disease (CKD), as well as maintenance dialysis and adversely affects the quality of life (QOL) of these patients. It has been reported to range from 20% to as high as 90%. The mechanism of CKD-associated pruritus (CKD-aP) has not been clearly identified, and many theories have been proposed to explain it. Many risk factors have been found to be associated with CKD-aP. The pruritus in CKD presents with diverse clinical features, and there are no set features to diagnose it.The patients with CKD-aP are mainly treated by nephrologists, primary care doctors, and dermatologists. Many treatments have been tried but nothing has been effective. The search of literature included peer-reviewed articles, including clinical trials and scientific reviews. Literature was identified through March 2021, and references of respective articles and only articles published in the English language were included.

Citing Articles

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Successful Use of Difelikefalin in Severe Chronic Kidney Disease-Associated Pruritus in a Patient With Complex Etiological Contributors: A Case Report.

Werzowa J, Hemetsberger M Case Rep Nephrol. 2025; 2025:6626611.

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Skrzypczak T, Skrzypczak A, Nockowski P, Szepietowski J Int J Nephrol Renovasc Dis. 2025; 17:339-354.

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The association Malnutrition-Inflammation Score with chronic kidney disease-associated pruritus and quality of life in hemodialysis patients: a multicenter cross-sectional study.

Bavi Behbahani H, Alipour M, Javid A, Razmi H, Tofighzadeh P, Fayazfar F Sci Rep. 2024; 14(1):31811.

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Difelikefalin in the treatment of hemodialysis patients with pruritus: a systematic review and meta-analysis.

Cai X, Wu G, Lin Y, Yang L Front Pharmacol. 2024; 15:1476587.

PMID: 39712488 PMC: 11659018. DOI: 10.3389/fphar.2024.1476587.

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