Matrix-Bound Growth Factors Are Released Upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux That is Lost in Osteoarthritis

Overview

Journal Function (Oxf)

Publisher Oxford University Press

Date 2021 Aug 23

PMID 34423304

Citations 11

Authors

Stuart J Keppie

Jessica C Mansfield

Xiaodi Tang

Christopher J Philp

Helen K Graham

Patrik Onnerfjord

Alanna Wall

Celia McLean

C Peter Winlove

Michael J Sherratt

Galina E Pavlovskaya

Tonia L Vincent

Affiliations

Soon will be listed here.

Abstract

Significance Statement: Osteoarthritis is the most prevalent musculoskeletal disease, affecting 250 million people worldwide. We identify a novel intrinsic repair response in cartilage, mediated by aggrecan-dependent sodium flux, and dependent upon matrix stiffness, which results in the release of a cocktail of pro-regenerative growth factors after injury. Loss of aggrecan in late-stage osteoarthritis prevents growth factor release and likely contributes to disease progression. Treatments that restore matrix sodium in osteoarthritis may recover the intrinsic repair response to improve disease outcome.

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