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Neural Circuit Function Redundancy in Brain Disorders

Overview
Specialties Biology
Neurology
Date 2021 Aug 20
PMID 34416675
Citations 9
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Abstract

Redundancy is a ubiquitous property of the nervous system. This means that vastly different configurations of cellular and synaptic components can enable the same neural circuit functions. However, until recently, very little brain disorder research has considered the implications of this characteristic when designing experiments or interpreting data. Here, we first summarise the evidence for redundancy in healthy brains, explaining redundancy and three related sub-concepts: sloppiness, dependencies and multiple solutions. We then lay out key implications for brain disorder research, covering recent examples of redundancy effects in experimental studies on psychiatric disorders. Finally, we give predictions for future experiments based on these concepts.

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References
1.
Ellingford R, Panasiuk M, de Meritens E, Shaunak R, Naybour L, Browne L . Cell-type-specific synaptic imbalance and disrupted homeostatic plasticity in cortical circuits of ASD-associated Chd8 haploinsufficient mice. Mol Psychiatry. 2021; 26(7):3614-3624. PMC: 8505247. DOI: 10.1038/s41380-021-01070-9. View

2.
Bulow P, Murphy T, Bassell G, Wenner P . Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons. Cell Rep. 2019; 26(6):1378-1388.e3. PMC: 6443253. DOI: 10.1016/j.celrep.2019.01.035. View

3.
Haddad S, Marder E . Circuit Robustness to Temperature Perturbation Is Altered by Neuromodulators. Neuron. 2018; 100(3):609-623.e3. PMC: 6613981. DOI: 10.1016/j.neuron.2018.08.035. View

4.
Goncalves J, Anstey J, Golshani P, Portera-Cailliau C . Circuit level defects in the developing neocortex of Fragile X mice. Nat Neurosci. 2013; 16(7):903-9. PMC: 3695061. DOI: 10.1038/nn.3415. View

5.
Rathour R, Narayanan R . Homeostasis of functional maps in active dendrites emerges in the absence of individual channelostasis. Proc Natl Acad Sci U S A. 2014; 111(17):E1787-96. PMC: 4035944. DOI: 10.1073/pnas.1316599111. View