Bioengineering the Cardiac Conduction System: Advances in Cellular, Gene, and Tissue Engineering for Heart Rhythm Regeneration

Overview

Journal Front Bioeng Biotechnol

Date 2021 Aug 19

PMID 34409019

Citations 5

Authors

Nataliia Naumova

Laura Iop

Affiliations

Soon will be listed here.

Abstract

Heart rhythm disturbances caused by different etiologies may affect pediatric and adult patients with life-threatening consequences. When pharmacological therapy is ineffective in treating the disturbances, the implantation of electronic devices to control and/or restore normal heart pacing is a unique clinical management option. Although these artificial devices are life-saving, they display many limitations; not least, they do not have any capability to adapt to somatic growth or respond to neuroautonomic physiological changes. A biological pacemaker could offer a new clinical solution for restoring heart rhythms in the conditions of disorder in the cardiac conduction system. Several experimental approaches, such as cell-based, gene-based approaches, and the combination of both, for the generation of biological pacemakers are currently established and widely studied. Pacemaker bioengineering is also emerging as a technology to regenerate nodal tissues. This review analyzes and summarizes the strategies applied so far for the development of biological pacemakers, and discusses current translational challenges toward the first-in-human clinical application.

Citing Articles

Pacemaker Channels and the Chronotropic Response in Health and Disease.

Hennis K, Piantoni C, Biel M, Fenske S, Wahl-Schott C Circ Res. 2024; 134(10):1348-1378.

PMID: 38723033 PMC: 11081487. DOI: 10.1161/CIRCRESAHA.123.323250.

Heart rhythm : measuring stem cell-derived pacemaker cells on microelectrode arrays.

Kussauer S, Dilk P, Elleisy M, Michaelis C, Lichtwark S, Rimmbach C Front Cardiovasc Med. 2024; 11:1200786.

PMID: 38450366 PMC: 10915086. DOI: 10.3389/fcvm.2024.1200786.

Advances in the design, generation, and application of tissue-engineered myocardial equivalents.

Bernava G, Iop L Front Bioeng Biotechnol. 2023; 11:1247572.

PMID: 37811368 PMC: 10559975. DOI: 10.3389/fbioe.2023.1247572.

Harnessing cell reprogramming for cardiac biological pacing.

Liu C, Chen Y, Hu Y J Biomed Sci. 2023; 30(1):74.

PMID: 37633890 PMC: 10463311. DOI: 10.1186/s12929-023-00970-y.

Sinus node dysfunction: current understanding and future directions.

Manoj P, Kim J, Kim S, Li T, Sewani M, Chelu M Am J Physiol Heart Circ Physiol. 2022; 324(3):H259-H278.

PMID: 36563014 PMC: 9886352. DOI: 10.1152/ajpheart.00618.2022.

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