Positive Chronotropic Effect Caused by Transthoracic Ultrasound in Heart of Rats

Overview

Journal JASA Express Lett

Specialties Biophysics
Otorhinolaryngology

Date 2021 Aug 16

PMID 34396365

Authors

Olivia C Coiado

Rahul S Yerrabelli

Anton P Christensen

Marcin Wozniak

Alex Lucas

William D OBrien Jr

Affiliations

Soon will be listed here.

Abstract

Pulsed ultrasound can produce chronotropic and inotropic effects on the heart with potential therapeutic applications. Fourteen 3-month-old female rats were exposed transthoracically to 3.5-MHz 2.0-MPa peak rarefactional pressure amplitude ultrasonic pulses of increasing 5-s duration pulse repetition frequency (PRF) sequences. An increase in the heart rate was observed following each PRF sequence: an ∼50% increase after the 4-5-6 Hz sequence, an ∼57% increase after the 5-6-7 Hz sequence, and an ∼48% increase after the 6-7-8 Hz sequence. Other cardiac parameters showed a normal or indicated a compensatory decrease at 3 and 15 min post-ultrasound compared to control.

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