Case Report: A Re-Positive Case of SARS-CoV-2 Associated With Glaucoma

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Aug 16

PMID 34394095

Citations 8

Authors

Xiaoli Zhou

Ya-Na Zhou

Ashaq Ali

Cuiqin Liang

Zhiqin Ye

Xiaomin Chen

Qing Zhang

Lihua Deng

Xinyi Sun

Qian Zhang

Jihong Luo

Wei Li

Kun Zhou

Shanshan Cao

Xiaowei Zhang

Xiao-Dong Li

Xian-En Zhang

Zongqiang Cui

Dong Men

Affiliations

Soon will be listed here.

Abstract

The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has already become a global threat to the human population. Infection with SARS-CoV-2 leads to a wide spectrum of clinical manifestations. Ocular abnormalities have been reported in association with COVID-19, but the nature of the impairments was not specified. Here, we report a case of a female patient diagnosed with glaucoma on re-hospitalization for ocular complications two months after being discharged from the hospital upon recovery from COVID-19. Meanwhile, the patient was found re-positive for SARS-CoV-2 in the upper respiratory tract. The infection was also diagnosed in the aqueous humor through immunostaining with antibodies against the N protein and S protein of SARS-CoV-2. Considering the eye is an immune-privileged site, we speculate that SARS-CoV-2 survived in the eye and resulted in the patient testing re-positive for SARS-CoV-2.

Citing Articles

Ocular neuroinflammatory response secondary to SARS-CoV-2 infection-a review.

Zhao Y, Tang Y, Wang Q, Li J Front Immunol. 2025; 16:1515768.

PMID: 39967658 PMC: 11832381. DOI: 10.3389/fimmu.2025.1515768.

SARS-CoV-2 infects cells lining the blood-retinal barrier and induces a hyperinflammatory immune response in the retina via systemic exposure.

Monu M, Ahmad F, Olson R, Balendiran V, Singh P PLoS Pathog. 2024; 20(4):e1012156.

PMID: 38598560 PMC: 11034659. DOI: 10.1371/journal.ppat.1012156.

Manifestations of coronavirus infection disease-19 in anterior eye segment: An up-to-date review.

Marzoog B Oman J Ophthalmol. 2024; 17(1):4-10.

PMID: 38524336 PMC: 10957037. DOI: 10.4103/ojo.ojo_237_22.

The Outbreak of Acute Primary Angle-Closure Cases During the COVID-19 Omicron Variant Pandemic at a Tertiary Eye Center in Shanghai.

Huang H, Dai Y, Sun X, Fang Y Clin Ophthalmol. 2024; 17:4009-4019.

PMID: 38162694 PMC: 10757803. DOI: 10.2147/OPTH.S440740.

New-onset Glaucoma Following Moderna COVID-19 Vaccination.

Su Y, Yeh S, Chen M J Curr Glaucoma Pract. 2023; 17(2):106-109.

PMID: 37485459 PMC: 10357024. DOI: 10.5005/jp-journals-10078-1408.

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