Pancreas-Brain Crosstalk

Overview

Journal Front Neuroanat

Date 2021 Aug 6

PMID 34354571

Citations 9

Authors

Battuvshin Lkhagvasuren

Onanong Mee-Inta

Zi-Wei Zhao

Tetsuya Hiramoto

Damdindorj Boldbaatar

Yu-Min Kuo

Affiliations

Soon will be listed here.

Abstract

The neural regulation of glucose homeostasis in normal and challenged conditions involves the modulation of pancreatic islet-cell function. Compromising the pancreas innervation causes islet autoimmunity in type 1 diabetes and islet cell dysfunction in type 2 diabetes. However, despite the richly innervated nature of the pancreas, islet innervation remains ill-defined. Here, we review the neuroanatomical and humoral basis of the cross-talk between the endocrine pancreas and autonomic and sensory neurons. Identifying the neurocircuitry and neurochemistry of the neuro-insular network would provide clues to neuromodulation-based approaches for the prevention and treatment of diabetes and obesity.

Citing Articles

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