Short Sleep Duration Disrupts Glucose Metabolism: Can Exercise Turn Back the Clock?

Overview

Journal Exerc Sport Sci Rev

Specialty Orthopedics

Date 2024 Apr 12

PMID 38608214

Authors

Alan Maloney

Jill A Kanaley

Affiliations

Soon will be listed here.

Abstract

Short sleep duration is prevalent in modern society and may be contributing to type 2 diabetes prevalence. This review will explore the effects of sleep restriction on glycemic control, the mechanisms causing insulin resistance, and whether exercise can offset changes in glycemic control. Chronic sleep restriction may also contribute to a decrease in physical activity leading to further health complications.

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References

Karakelides H, Irving B, Short K, OBrien P, Nair K . Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function. Diabetes. 2009; 59(1):89-97. PMC: 2797949. DOI: 10.2337/db09-0591. View

Lorenzo C, Williams K, Haffner S . Insulin secretion based on the late oral glucose tolerance test period and incident diabetes: the San Antonio Heart Study. Diabet Med. 2012; 29(8):e151-8. PMC: 3391351. DOI: 10.1111/j.1464-5491.2012.03660.x. View

Hargreaves M . Exercise and health: historical perspectives and new insights. J Appl Physiol (1985). 2021; 131(2):575-588. DOI: 10.1152/japplphysiol.00242.2021. View

Thomas M, Sing H, Belenky G, Holcomb H, Mayberg H, Dannals R . Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity. J Sleep Res. 2000; 9(4):335-52. DOI: 10.1046/j.1365-2869.2000.00225.x. View

Eckel R, Alberti K, Grundy S, Zimmet P . The metabolic syndrome. Lancet. 2010; 375(9710):181-3. DOI: 10.1016/S0140-6736(09)61794-3. View

Brouwer A, van Raalte D, Nguyen H, Rutters F, van de Ven P, Elders P . Effects of Light Therapy on Mood and Insulin Sensitivity in Patients With Type 2 Diabetes and Depression: Results From a Randomized Placebo-Controlled Trial. Diabetes Care. 2019; 42(4):529-538. DOI: 10.2337/dc18-1732. View

Gregory J, Muldowney J, Engelhardt B, Tyree R, Marks-Shulman P, Silver H . Aerobic exercise training improves hepatic and muscle insulin sensitivity, but reduces splanchnic glucose uptake in obese humans with type 2 diabetes. Nutr Diabetes. 2019; 9(1):25. PMC: 6717736. DOI: 10.1038/s41387-019-0090-0. View

Dube S, Errazuriz I, Cobelli C, Basu R, Basu A . Assessment of insulin action on carbohydrate metabolism: physiological and non-physiological methods. Diabet Med. 2013; 30(6):664-70. PMC: 3662485. DOI: 10.1111/dme.12189. View

Garcia G, FREEMAN R, Supiano M, Smith M, Galecki A, Halter J . Glucose metabolism in older adults: a study including subjects more than 80 years of age. J Am Geriatr Soc. 1997; 45(7):813-7. DOI: 10.1111/j.1532-5415.1997.tb01507.x. View

10.

Rehman K, Akash M, Liaqat A, Kamal S, Qadir M, Rasul A . Role of Interleukin-6 in Development of Insulin Resistance and Type 2 Diabetes Mellitus. Crit Rev Eukaryot Gene Expr. 2017; 27(3):229-236. DOI: 10.1615/CritRevEukaryotGeneExpr.2017019712. View

11.

Bergouignan A, Latouche C, Heywood S, Grace M, Reddy-Luthmoodoo M, Natoli A . Frequent interruptions of sedentary time modulates contraction- and insulin-stimulated glucose uptake pathways in muscle: Ancillary analysis from randomized clinical trials. Sci Rep. 2016; 6:32044. PMC: 4995429. DOI: 10.1038/srep32044. View

12.

Sweeney E, Jeromson S, Hamilton D, Brooks N, Walshe I . Skeletal muscle insulin signaling and whole-body glucose metabolism following acute sleep restriction in healthy males. Physiol Rep. 2017; 5(23). PMC: 5727269. DOI: 10.14814/phy2.13498. View

13.

Porter J, Pettit-Mee R, Emerson T, McCrae C, Lastra G, Vieira-Potter V . Modest sleep restriction does not influence steps, physical activity intensity or glucose tolerance in obese adults. J Sleep Res. 2021; 30(6):e13381. PMC: 10315064. DOI: 10.1111/jsr.13381. View

14.

Bosy-Westphal A, Hinrichs S, Jauch-Chara K, Hitze B, Later W, Wilms B . Influence of partial sleep deprivation on energy balance and insulin sensitivity in healthy women. Obes Facts. 2010; 1(5):266-73. PMC: 6515888. DOI: 10.1159/000158874. View

15.

Lee S, Ng K, Chin W . The impact of sleep amount and sleep quality on glycemic control in type 2 diabetes: A systematic review and meta-analysis. Sleep Med Rev. 2016; 31:91-101. DOI: 10.1016/j.smrv.2016.02.001. View

16.

Wilms B, Leineweber E, Molle M, Chamorro R, Pommerenke C, Salinas-Riester G . Sleep Loss Disrupts Morning-to-Evening Differences in Human White Adipose Tissue Transcriptome. J Clin Endocrinol Metab. 2018; 104(5):1687-1696. DOI: 10.1210/jc.2018-01663. View

17.

Srikanthan P, Karlamangla A . Relative muscle mass is inversely associated with insulin resistance and prediabetes. Findings from the third National Health and Nutrition Examination Survey. J Clin Endocrinol Metab. 2011; 96(9):2898-903. DOI: 10.1210/jc.2011-0435. View

18.

Saner N, Lee M, Pitchford N, Kuang J, Roach G, Garnham A . The effect of sleep restriction, with or without high-intensity interval exercise, on myofibrillar protein synthesis in healthy young men. J Physiol. 2020; 598(8):1523-1536. PMC: 7217042. DOI: 10.1113/JP278828. View

19.

Faraut B, Boudjeltia K, Dyzma M, Rousseau A, David E, Stenuit P . Benefits of napping and an extended duration of recovery sleep on alertness and immune cells after acute sleep restriction. Brain Behav Immun. 2010; 25(1):16-24. DOI: 10.1016/j.bbi.2010.08.001. View

20.

Lin W, Saner N, Weng X, Caruana N, Botella J, Kuang J . The Effect of Sleep Restriction, With or Without Exercise, on Skeletal Muscle Transcriptomic Profiles in Healthy Young Males. Front Endocrinol (Lausanne). 2022; 13:863224. PMC: 9355502. DOI: 10.3389/fendo.2022.863224. View