Long Non-coding RNA T-uc.189 Modulates Neural Progenitor Cell Fate by Regulating During Mouse Cerebral Cortex Development

Overview

Journal Front Neurosci

Date 2021 Aug 6

PMID 34354569

Citations 1

Authors

Meng Zhang

Junjie Zhou

Li Jiao

Longjiang Xu

Lin Hou

Bin Yin

Boqin Qiang

Shuaiyao Lu

Pengcheng Shu

Xiaozhong Peng

Affiliations

Soon will be listed here.

Abstract

Neurogenesis is a complex process that depends on the delicate regulation of spatial and temporal gene expression. In our previous study, we found that transcribed ultra-conserved regions (T-UCRs), a class of long non-coding RNAs that contain UCRs, are expressed in the developing nervous systems of mice, rhesus monkeys, and humans. In this study, we first detected the full-length sequence of T-uc.189, revealing that it was mainly concentrated in the ventricular zone (VZ) and that its expression decreased as the brain matured. Moreover, we demonstrated that knockdown of T-uc.189 inhibited neurogenesis. In addition, we found that T-uc.189 positively regulated the expression of serine-arginine-rich splicing factor 3 (). Taken together, our results are the first to demonstrate that T-uc.189 regulates the expression of to maintain normal neurogenesis during cortical development.

Citing Articles

Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential.

Wang T, Li F, Lu Z Discov Oncol. 2023; 14(1):41.

PMID: 37036543 PMC: 10086085. DOI: 10.1007/s12672-023-00650-1.

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