Genus: Enlightening Phytochemical Components for Pharmacological and Health-Promoting Abilities

Overview

Journal Oxid Med Cell Longev

Publisher Wiley

Specialties Cell Biology
Endocrinology

Date 2021 Aug 5

PMID 34349875

Citations 34

Authors

Javad Sharifi-Rad

Cristina Quispe

Jesus Herrera-Bravo

Lisandra Herrera Belen

Rajandeep Kaur

Dorota Kregiel

Yadav Uprety

Ahmet Beyatli

Balakyz Yeskaliyeva

Celale Kirkin

Beraat Ozcelik

Surjit Sen

Krishnendu Acharya

Farukh Sharopov

Natalia Cruz-Martins

Manoj Kumar

Ahmad Faizal Abdull Razis

Usman Sunusi

Ramla Muhammad Kamal

Shabnum Shaheen

Hafiz Ansar Rasul Suleria

Affiliations

Soon will be listed here.

Abstract

The genus, generally well-known as licorice, is broadly used for food and medicinal purposes around the globe. The genus encompasses a rich pool of bioactive molecules including triterpene saponins (e.g., glycyrrhizin) and flavonoids (e.g., liquiritigenin, liquiritin). This genus is being increasingly exploited for its biological effects such as antioxidant, antibacterial, antifungal, anti-inflammatory, antiproliferative, and cytotoxic activities. The species L. and the compound glycyrrhizin (glycyrrhizic acid) have been studied immensely for their effect on humans. The efficacy of the compound has been reported to be significantly higher on viral hepatitis and immune deficiency syndrome. This review provides up-to-date data on the most widely investigated species for food and medicinal purposes, with special emphasis on secondary metabolites' composition and bioactive effects.

Citing Articles

Glycyrrhizin Alleviates the Damage Caused by Zearalenone and Protects the Glandular Stomach of Chickens.

Sun T, Wang F, Qian M, Wang J, Guo M Animals (Basel). 2025; 15(4).

PMID: 40002971 PMC: 11851901. DOI: 10.3390/ani15040489.

Jinhua Qinggan Granule UHPLC-Q-extractive-Orbitrap-MS assay: Putative identification of 45 potential anti-Covid-19 constituents, confidential addition, and pharmacopoeia quality-markers recommendation.

Zeng J, Li X, Cai R, Li C, Chen S J Food Drug Anal. 2024; 31(3):534-551.

PMID: 39666276 PMC: 10629912. DOI: 10.38212/2224-6614.3466.

Putative Identification of 47 Compounds from Jieyu Anshen Granule and Proposal of Pharmacopeia Quality-Assessment Strategy Using TCM-Specific Library with UHPLC-Q-Exactive-Orbitrap-MS.

Li X, Zeng J, Cai R, Li C, Chen X, Chen B ChemistryOpen. 2024; 14(1):e202400046.

PMID: 39569900 PMC: 11726651. DOI: 10.1002/open.202400046.

Effects of Licorice Functional Components Intakes on Blood Pressure: A Systematic Review with Meta-Analysis and NETWORK Toxicology.

Wu T, Yang J, Xia J, Sun G Nutrients. 2024; 16(21).

PMID: 39519602 PMC: 11547873. DOI: 10.3390/nu16213768.

Exploring the Role of Licorice and Its Derivatives in Cell Signaling Pathway NF-B and MAPK.

Fatima I, Sahar A, Tariq A, Naz T, Usman M J Nutr Metab. 2024; 2024:9988167.

PMID: 39479405 PMC: 11524698. DOI: 10.1155/2024/9988167.

References

Hajirahimkhan A, Simmler C, Yuan Y, Anderson J, Chen S, Nikolic D . Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms. PLoS One. 2013; 8(7):e67947. PMC: 3709979. DOI: 10.1371/journal.pone.0067947. View

Harada T, Ohtaki E, Misu K, Sumiyoshi T, Hosoda S . Congestive heart failure caused by digitalis toxicity in an elderly man taking a licorice-containing chinese herbal laxative. Cardiology. 2003; 98(4):218. DOI: 10.1159/000067316. View

Wang J, Liao A, Thakur K, Zhang J, Huang J, Wei Z . Licochalcone B Extracted from Glycyrrhiza uralensis Fisch Induces Apoptotic Effects in Human Hepatoma Cell HepG2. J Agric Food Chem. 2019; 67(12):3341-3353. DOI: 10.1021/acs.jafc.9b00324. View

Rizzato G, Scalabrin E, Radaelli M, Capodaglio G, Piccolo O . A new exploration of licorice metabolome. Food Chem. 2016; 221:959-968. DOI: 10.1016/j.foodchem.2016.11.068. View

Kirmizibekmez H, Uysal G, Masullo M, Demirci F, Bagci Y, Kan Y . Prenylated polyphenolic compounds from Glycyrrhiza iconica and their antimicrobial and antioxidant activities. Fitoterapia. 2015; 103:289-93. DOI: 10.1016/j.fitote.2015.05.003. View

Acharya S, Dasarathy S, Tandon A, Joshi Y, Tandon B . A preliminary open trial on interferon stimulator (SNMC) derived from Glycyrrhiza glabra in the treatment of subacute hepatic failure. Indian J Med Res. 1993; 98:69-74. View

Nafisi S, Manouchehri F, Bonsaii M . Study on the interaction of glycyrrhizin and glycyrrhetinic acid with RNA. J Photochem Photobiol B. 2012; 111:27-34. DOI: 10.1016/j.jphotobiol.2012.03.006. View

Ahn S, Park S, Lee Y, Cho E, Lim Y, Li X . In vitro antimicrobial activities of 1-methoxyficifolinol, licorisoflavan A, and 6,8-diprenylgenistein against Streptococcus mutans. Caries Res. 2014; 49(1):78-89. DOI: 10.1159/000362676. View

Hayashi H, Fujii I, Iinuma M, Shibano M, Ozaki K, Watanabe H . Characterization of a glycyrrhizin-deficient strain of Glycyrrhiza uralensis. Biol Pharm Bull. 2013; 36(9):1448-53. DOI: 10.1248/bpb.b13-00164. View

10.

Penninkilampi R, Eslick E, Eslick G . The association between consistent licorice ingestion, hypertension and hypokalaemia: a systematic review and meta-analysis. J Hum Hypertens. 2017; 31(11):699-707. DOI: 10.1038/jhh.2017.45. View

11.

Cantelli-Forti G, Maffei F, Hrelia P, Bugamelli F, Bernardi M, DIntino P . Interaction of licorice on glycyrrhizin pharmacokinetics. Environ Health Perspect. 1994; 102 Suppl 9:65-8. PMC: 1566785. DOI: 10.1289/ehp.94102s965. View

12.

Chakotiya A, Tanwar A, Srivastava P, Narula A, Sharma R . Effect of aquo-alchoholic extract of Glycyrrhiza glabra against Pseudomonas aeruginosa in Mice Lung Infection Model. Biomed Pharmacother. 2017; 90:171-178. DOI: 10.1016/j.biopha.2017.03.055. View

13.

Strandberg T, Andersson S, Jarvenpaa A, McKeigue P . Preterm birth and licorice consumption during pregnancy. Am J Epidemiol. 2002; 156(9):803-5. DOI: 10.1093/aje/kwf130. View

14.

Xie Y, Dong X, Wu X, Yan X, Xie Q . Inhibitory effects of flavonoids extracted from licorice on lipopolysaccharide-induced acute pulmonary inflammation in mice. Int Immunopharmacol. 2008; 9(2):194-200. DOI: 10.1016/j.intimp.2008.11.004. View

15.

Raikkonen K, Pesonen A, Heinonen K, Lahti J, Komsi N, Eriksson J . Maternal licorice consumption and detrimental cognitive and psychiatric outcomes in children. Am J Epidemiol. 2009; 170(9):1137-46. DOI: 10.1093/aje/kwp272. View

16.

Schmid C, Dawid C, Peters V, Hofmann T . Saponins from European Licorice Roots ( Glycyrrhiza glabra). J Nat Prod. 2018; 81(8):1734-1744. DOI: 10.1021/acs.jnatprod.8b00022. View

17.

Khajoei Nasab F, Khosravi A . Ethnobotanical study of medicinal plants of Sirjan in Kerman Province, Iran. J Ethnopharmacol. 2014; 154(1):190-7. DOI: 10.1016/j.jep.2014.04.003. View

18.

Yamaguchi H, Kidachi Y, Kamiie K, Noshita T, Umetsu H, Ryoyama K . Glycyrrhetinic acid induces anoikis-like death and cytoskeletal disruption in the central nervous system tumorigenic cells. Biol Pharm Bull. 2010; 33(2):321-4. DOI: 10.1248/bpb.33.321. View

19.

Haraguchi H, Yoshida N, Ishikawa H, Tamura Y, Mizutani K, Kinoshita T . Protection of mitochondrial functions against oxidative stresses by isoflavans from Glycyrrhiza glabra. J Pharm Pharmacol. 2000; 52(2):219-23. DOI: 10.1211/0022357001773724. View

20.

Hong Y, Wu H, Ma T, Liu W, He X . Effects of Glycyrrhiza glabra polysaccharides on immune and antioxidant activities in high-fat mice. Int J Biol Macromol. 2009; 45(1):61-4. DOI: 10.1016/j.ijbiomac.2009.04.001. View