EGR1 Promoted Anticancer Effects of Scutellarin Via Regulating LINC00857/miR-150-5p/c-Myc in Osteosarcoma

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2021 Aug 4

PMID 34346162

Citations 5

Authors

Jian Han

Peng Wang

Xin Xia

Li Zhang

He Zhang

Yu Huang

Xiaodong Li

Wenzhi Zhao

Lu Zhang

Affiliations

Soon will be listed here.

Abstract

Scutellarin, an active flavone extracted from Erigeron breviscapus, is known to exhibit antitumour activity in many cancers. However, the effects of Scutellarin on osteosarcoma remain unclear. In this study, we found that Scutellarin suppressed osteosarcoma cell growth, induced cell apoptosis and inhibited tumorigenesis. Mechanistically, our data revealed that EGR1 was significantly increased under Scutellarin treatment. Increased EGR1 enhanced tumour-suppressive effects of Scutellarin on osteosarcoma cells via transcriptionally downregulating LINC00857 expression. Additionally, we found that LINC00857 acted as a competitive endogenous RNA of miR-150-5p and inhibited the activity of miR-150-5p, which resulted in c-Myc increase. Scutellarin could suppress c-Myc protein levels through decreasing LINC00857 expression in osteosarcoma. Thus, these findings demonstrate that EGR1/ LINC00857/miR-150-5p/c-Myc axis plays a key role in promoting anticancer effects of Scutellarin and Scutellarin might have potential clinical implication in osteosarcoma clinical treatment.

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EGR1 promoted anticancer effects of Scutellarin via regulating LINC00857/miR-150-5p/c-Myc in osteosarcoma.

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