Whole-body Magnetic Resonance Imaging (WB-MRI) for Cancer Screening: Recommendations for Use

Overview

Journal Radiol Med

Specialty Radiology

Date 2021 Aug 2

PMID 34338948

Citations 31

Authors

Giuseppe Petralia

Fabio Zugni

Paul E Summers

Alberto Colombo

Paola Pricolo

Luigi Grazioli

Stefano Colagrande

Andrea Giovagnoni

Anwar R Padhani

Affiliations

Soon will be listed here.

Abstract

Whole-body magnetic resonance imaging (WB-MRI) is currently recommended for cancer screening in adult and paediatric subjects with cancer predisposition syndromes, representing a substantial aid for prolonging health and survival of these subjects with a high oncological risk. Additionally, the number of studies exploring the use of WB-MRI for cancer screening in asymptomatic subjects from the general population is growing. The primary aim of this review was to analyse the acquisition protocols found in the literature, in order to identify common sequences across published studies and to discuss the need of additional ones for specific populations. The secondary aim of this review was to provide a synthesis of current recommendations regarding the use of WB-MRI for cancer screening.

Citing Articles

Prenatal cfDNA Sequencing and Incidental Detection of Maternal Cancer.

Turriff A, Annunziata C, Malayeri A, Redd B, Pavelova M, Goldlust I N Engl J Med. 2025; 391(22):2123-2132.

PMID: 39774314 PMC: 11711700. DOI: 10.1056/NEJMoa2401029.

Added value of body MRI to detect primary abdominal malignancies in the diagnostic work-up of patients with adenocarcinoma of unknown primary.

Willemse J, Lahaye M, Goedegebuure E, Snaebjornsson P, Marchetti S, Vollebergh M Eur Radiol. 2024; .

PMID: 39470795 DOI: 10.1007/s00330-024-11149-w.

Multiparametric Whole-Body MRI: A Game Changer in Metastatic Prostate Cancer.

Cattabriga A, Renzetti B, Galuppi F, Bartalena L, Gaudiano C, Brocchi S Cancers (Basel). 2024; 16(14).

PMID: 39061171 PMC: 11274871. DOI: 10.3390/cancers16142531.

Whole-Body MRI Screening for Carriers of Germline TP53 Mutations-A Systematic Review and Meta-Analysis.

Temperley H, OSullivan N, Mac Curtain B, Qian W, Temperley T, Murray A J Clin Med. 2024; 13(5).

PMID: 38592011 PMC: 10931931. DOI: 10.3390/jcm13051223.

An Updated Review on Imaging and Staging of Anal Cancer-Not Just Rectal Cancer.

Congedo A, Mallardi D, Danti G, De Muzio F, Granata V, Miele V Tomography. 2023; 9(5):1694-1710.

PMID: 37736988 PMC: 10514831. DOI: 10.3390/tomography9050135.

References

Reilly K, Kim A, Blakely J, Ferner R, Gutmann D, Legius E . Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future. J Natl Cancer Inst. 2017; 109(8). PMC: 6057517. DOI: 10.1093/jnci/djx124. View

Padhani A, Lecouvet F, Tunariu N, Koh D, De Keyzer F, Collins D . METastasis Reporting and Data System for Prostate Cancer: Practical Guidelines for Acquisition, Interpretation, and Reporting of Whole-body Magnetic Resonance Imaging-based Evaluations of Multiorgan Involvement in Advanced Prostate Cancer. Eur Urol. 2016; 71(1):81-92. PMC: 5176005. DOI: 10.1016/j.eururo.2016.05.033. View

Rangel E . The management of incidental findings in neuro-imaging research: framework and recommendations. J Law Med Ethics. 2010; 38(1):117-26. DOI: 10.1111/j.1748-720X.2010.00471.x. View

Tunariu N, Blackledge M, Messiou C, Petralia G, Padhani A, Curcean S . What's New for Clinical Whole-body MRI (WB-MRI) in the 21st Century. Br J Radiol. 2020; 93(1115):20200562. PMC: 8519652. DOI: 10.1259/bjr.20200562. View

Liu T, Wang S, Liu H, Meng B, Zhou F, He F . Detection of vertebral metastases: a meta-analysis comparing MRI, CT, PET, BS and BS with SPECT. J Cancer Res Clin Oncol. 2016; 143(3):457-465. DOI: 10.1007/s00432-016-2288-z. View

Kim J, Rini B, Hansel D . Von Hippel Lindau syndrome. Adv Exp Med Biol. 2010; 685:228-49. DOI: 10.1007/978-1-4419-6448-9_22. View

Tonsgard J . Clinical manifestations and management of neurofibromatosis type 1. Semin Pediatr Neurol. 2006; 13(1):2-7. DOI: 10.1016/j.spen.2006.01.005. View

Taylor S, Mallett S, Beare S, Bhatnagar G, Blunt D, Boavida P . Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed colorectal cancer: the prospective Streamline C trial. Lancet Gastroenterol Hepatol. 2019; 4(7):529-537. PMC: 6547166. DOI: 10.1016/S2468-1253(19)30056-1. View

Porter D, Lonie L, Fraser M, Dobson-Stone C, Porter J, Monaco A . Severity of disease and risk of malignant change in hereditary multiple exostoses. A genotype-phenotype study. J Bone Joint Surg Br. 2004; 86(7):1041-6. DOI: 10.1302/0301-620x.86b7.14815. View

10.

Petralia G, Koh D, Attariwala R, Busch J, Eeles R, Karow D . Oncologically Relevant Findings Reporting and Data System (ONCO-RADS): Guidelines for the Acquisition, Interpretation, and Reporting of Whole-Body MRI for Cancer Screening. Radiology. 2021; 299(3):494-507. DOI: 10.1148/radiol.2021201740. View

11.

Takahara T, Kwee T, Kibune S, Ochiai R, Sakamoto T, Niwa T . Whole-body MRI using a sliding table and repositioning surface coil approach. Eur Radiol. 2009; 20(6):1366-73. PMC: 2861758. DOI: 10.1007/s00330-009-1674-1. View

12.

Mai P, Best A, Peters J, DeCastro R, Khincha P, Loud J . Risks of first and subsequent cancers among TP53 mutation carriers in the National Cancer Institute Li-Fraumeni syndrome cohort. Cancer. 2016; 122(23):3673-3681. PMC: 5115949. DOI: 10.1002/cncr.30248. View

13.

Cashen D, Parisien R, Raskin K, Hornicek F, Gebhardt M, Mankin H . Survival data for patients with malignant schwannoma. Clin Orthop Relat Res. 2004; (426):69-73. DOI: 10.1097/01.blo.0000131256.82455.c5. View

14.

Padhani A, Makris A, Gall P, Collins D, Tunariu N, de Bono J . Therapy monitoring of skeletal metastases with whole-body diffusion MRI. J Magn Reson Imaging. 2014; 39(5):1049-78. DOI: 10.1002/jmri.24548. View

15.

Disler D, McCauley T, RATNER L, Kesack C, Cooper J . In-phase and out-of-phase MR imaging of bone marrow: prediction of neoplasia based on the detection of coexistent fat and water. AJR Am J Roentgenol. 1997; 169(5):1439-47. DOI: 10.2214/ajr.169.5.9353477. View

16.

Schmidt G, Schoenberg S, Reiser M, Baur-Melnyk A . Whole-body MR imaging of bone marrow. Eur J Radiol. 2005; 55(1):33-40. DOI: 10.1016/j.ejrad.2005.01.019. View

17.

Baumgart D, Egelhof T . [Preventive whole-body screening encompassing modern imaging using magnetic resonance tomography]. Herz. 2007; 32(5):387-94. DOI: 10.1007/s00059-007-3020-1. View

18.

Friedman D, Lis E, Sklar C, Oeffinger K, Reppucci M, Fleischut M . Whole-body magnetic resonance imaging (WB-MRI) as surveillance for subsequent malignancies in survivors of hereditary retinoblastoma: a pilot study. Pediatr Blood Cancer. 2014; 61(8):1440-4. PMC: 4007376. DOI: 10.1002/pbc.24835. View

19.

Perkins B, Caskey C, Brar P, Dec E, Karow D, Kahn A . Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults. Proc Natl Acad Sci U S A. 2018; 115(14):3686-3691. PMC: 5889622. DOI: 10.1073/pnas.1706096114. View

20.

Shen G, Deng H, Hu S, Jia Z . Comparison of choline-PET/CT, MRI, SPECT, and bone scintigraphy in the diagnosis of bone metastases in patients with prostate cancer: a meta-analysis. Skeletal Radiol. 2014; 43(11):1503-13. DOI: 10.1007/s00256-014-1903-9. View