What Do Cochrane Systematic Reviews Say About Interventions for Vitamin D Supplementation?

Overview

Journal Sao Paulo Med J

Specialty General Medicine

Date 2017 Nov 9

PMID 29116314

Citations 5

Authors

Mariana Vendramin Mateussi

Carolina de Oliveira Cruz Latorraca

Julia Pozetti Daou

Ana Luiza Cabrera Martimbianco

Rachel Riera

Rafael Leite Pacheco

Daniela Vianna Pachito

Affiliations

Soon will be listed here.

Abstract

Context And Objective: Despite the high prevalence of vitamin D supplementation, its use remains controversial. The objective of this review was to identify and summarize the evidence from Cochrane systematic reviews regarding vitamin D supplementation for preventing ortreating any clinical condition.

Design And Setting: Review of systematic reviews, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo.

Methods: A search was conducted to identify all Cochrane systematic reviews that fulfilled the inclusion criteria. Titles and abstracts were screened by two authors.

Results: We included 27 Cochrane systematic reviews: 10 assessing use of vitamin D for prevention and 17 for treatment. The reviews found moderate to high quality of evidence regarding the benefit of vitamin D for pregnant women (prevention of adverse events: preterm birth risk [rate ratio, RR 0.36; 95% confidence interval, CI 0.14 to 0.93] and low birthweight risk [RR 0.40; 95% CI 0.24 to 0.67]) and for asthma patients (reduction of severe exacerbations [RR 0.63; 95% CI 0.45 to 0.88]). No benefit was found regarding vitamin D supplementation alone (without calcium) for preventing hip or any new fracture. For all other outcomes assessed under various conditions, the current quality of evidence is low or unknown, and therefore insufficient for any recommendation.

Conclusion: Based on moderate to high quality of evidence, the Cochrane systematic reviews included here showed that there were some benefits from vitamin D supplementation for pregnant women and asthma patients and no benefits for preventing fractures.

Citing Articles

Vitamin D status in Norwegian children and associations between child vitamin D status, dietary factors, and maternal vitamin D status.

Kristiansen A, Myhre J, Oyri L, Holven K, Andersen L Food Nutr Res. 2025; 69.

PMID: 39974838 PMC: 11836780. DOI: 10.29219/fnr.v69.10727.

Vitamin D - a scoping review for Nordic nutrition recommendations 2023.

Brustad M, Meyer H Food Nutr Res. 2023; 67.

PMID: 38084153 PMC: 10710863. DOI: 10.29219/fnr.v67.10230.

Factors Associated with Potentially Inappropriate Screening for Vitamin D Deficiency among Women in Medically Underserved Regions of West Texas.

Appiah D, Kamrudin S, de Riese C J Clin Med. 2023; 12(3).

PMID: 36769641 PMC: 9917744. DOI: 10.3390/jcm12030993.

A new taxonomy was developed for overlap across 'overviews of systematic reviews': A meta-research study of research waste.

Lunny C, Reid E, Neelakant T, Chen A, Zhang J, Shinger G Res Synth Methods. 2021; 13(3):315-329.

PMID: 34927388 PMC: 9303867. DOI: 10.1002/jrsm.1542.

The role of vitamin D in perinatology. An up-to-date review.

Ciebiera M, Wojtyla C, Lukaszuk K, Zgliczynska M, Zareba K, Rawski W Arch Med Sci. 2021; 17(4):992-1005.

PMID: 34336027 PMC: 8314414. DOI: 10.5114/aoms.2019.81747.

References

Soe H, Abas A, Than N, Ni H, Singh J, Said A . Vitamin D supplementation for sickle cell disease. Cochrane Database Syst Rev. 2017; 1:CD010858. PMC: 6464759. DOI: 10.1002/14651858.CD010858.pub2. View

Ferguson J, Chang A . Vitamin D supplementation for cystic fibrosis. Cochrane Database Syst Rev. 2014; (5):CD007298. PMC: 11254375. DOI: 10.1002/14651858.CD007298.pub4. View

De-Regil L, Palacios C, Lombardo L, Pena-Rosas J . Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2016; (1):CD008873. DOI: 10.1002/14651858.CD008873.pub3. View

Vecchio M, Navaneethan S, Johnson D, Lucisano G, Graziano G, Saglimbene V . Interventions for treating sexual dysfunction in patients with chronic kidney disease. Cochrane Database Syst Rev. 2010; (12):CD007747. DOI: 10.1002/14651858.CD007747.pub2. View

Avenell A, Smith T, Curtain J, Mak J, Myint P . Nutritional supplementation for hip fracture aftercare in older people. Cochrane Database Syst Rev. 2016; 11:CD001880. PMC: 6464805. DOI: 10.1002/14651858.CD001880.pub6. View

Gillespie L, Robertson M, Gillespie W, Sherrington C, Gates S, Clemson L . Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev. 2012; (9):CD007146. PMC: 8095069. DOI: 10.1002/14651858.CD007146.pub3. View

Bolignano D, Palmer S, Ruospo M, Zoccali C, Craig J, Strippoli G . Interventions for preventing the progression of autosomal dominant polycystic kidney disease. Cochrane Database Syst Rev. 2015; (7):CD010294. PMC: 8406618. DOI: 10.1002/14651858.CD010294.pub2. View

Palmer S, McGregor D, Strippoli G . Interventions for preventing bone disease in kidney transplant recipients. Cochrane Database Syst Rev. 2007; (3):CD005015. DOI: 10.1002/14651858.CD005015.pub3. View

Yakoob M, Salam R, Khan F, Bhutta Z . Vitamin D supplementation for preventing infections in children under five years of age. Cochrane Database Syst Rev. 2016; 11:CD008824. PMC: 5450876. DOI: 10.1002/14651858.CD008824.pub2. View

10.

Visser M, Durao S, Sinclair D, Irlam J, Siegfried N . Micronutrient supplementation in adults with HIV infection. Cochrane Database Syst Rev. 2017; 5:CD003650. PMC: 5458097. DOI: 10.1002/14651858.CD003650.pub4. View

11.

Hahn D, Hodson E, Craig J . Interventions for metabolic bone disease in children with chronic kidney disease. Cochrane Database Syst Rev. 2015; (11):CD008327. PMC: 7180137. DOI: 10.1002/14651858.CD008327.pub2. View

12.

Palmer S, McGregor D, Craig J, Elder G, Macaskill P, Strippoli G . Vitamin D compounds for people with chronic kidney disease not requiring dialysis. Cochrane Database Syst Rev. 2009; (4):CD008175. DOI: 10.1002/14651858.CD008175. View

13.

Jagannath V, Fedorowicz Z, Asokan G, Robak E, Whamond L . Vitamin D for the management of multiple sclerosis. Cochrane Database Syst Rev. 2010; (12):CD008422. DOI: 10.1002/14651858.CD008422.pub2. View

14.

Ranganathan L, Ramaratnam S . Vitamins for epilepsy. Cochrane Database Syst Rev. 2005; (2):CD004304. DOI: 10.1002/14651858.CD004304.pub2. View

15.

Straube S, Derry S, Straube C, Moore R . Vitamin D for the treatment of chronic painful conditions in adults. Cochrane Database Syst Rev. 2015; (5):CD007771. PMC: 6494161. DOI: 10.1002/14651858.CD007771.pub3. View

16.

Homik J, Suarez-Almazor M, Shea B, Cranney A, Wells G, Tugwell P . Calcium and vitamin D for corticosteroid-induced osteoporosis. Cochrane Database Syst Rev. 2000; (2):CD000952. PMC: 7046131. DOI: 10.1002/14651858.CD000952. View

17.

Bjelakovic G, Gluud L, Nikolova D, Whitfield K, Wetterslev J, Simonetti R . Vitamin D supplementation for prevention of mortality in adults. Cochrane Database Syst Rev. 2014; (1):CD007470. PMC: 11285307. DOI: 10.1002/14651858.CD007470.pub3. View

18.

Palmer S, McGregor D, Craig J, Elder G, Macaskill P, Strippoli G . Vitamin D compounds for people with chronic kidney disease requiring dialysis. Cochrane Database Syst Rev. 2009; (4):CD005633. DOI: 10.1002/14651858.CD005633.pub2. View

19.

Lerch C, Meissner T . Interventions for the prevention of nutritional rickets in term born children. Cochrane Database Syst Rev. 2007; (4):CD006164. PMC: 8990776. DOI: 10.1002/14651858.CD006164.pub2. View

20.

Grobler L, Nagpal S, Sudarsanam T, Sinclair D . Nutritional supplements for people being treated for active tuberculosis. Cochrane Database Syst Rev. 2016; (6):CD006086. PMC: 4981643. DOI: 10.1002/14651858.CD006086.pub4. View