The Contribution of Nano-based Strategies in Overcoming Ceftriaxone Resistance: a Literature Review

Overview

Journal Pharmacol Res Perspect

Date 2021 Jul 31

PMID 34331383

Citations 7

Authors

Ashagrachew Tewabe

Tesfa Marew

Gebremariam Birhanu

Affiliations

Soon will be listed here.

Abstract

Antimicrobial drug resistance, including resistance to multiple antibiotics, is continuously increasing. According to research findings, many bacteria resistant to other antibiotics were susceptible to ceftriaxone. However, over the last few years, ceftriaxone resistance has become growing and extremely worrisome challenge to the global healthcare system and several strategies have been initiated to contain the spread of antimicrobial drug resistance. Its extended use for therapeutic or preventative measures in humans and farm animals resulted in the development and spread of resistance. Recent advances in nanotechnology also offer novel formulations based on distinct types of nanostructure particles with different sizes and shapes, and flexible antimicrobial properties. For ceftriaxone, several nanostructured formulations through conjugation, intercalation, encapsulation with lipid carrier, and polymeric films have been investigated by different groups with promising results in combating the development of resistance. This review addressed the existing knowledge and practice on the contribution of nano-based delivery approaches in overcoming ceftriaxone resistance. Evidences have been generated from published research articles using major search electronic databases such as PubMed, Medline, Google Scholar, and Science Direct.

Citing Articles

How Combined Macrolide Nanomaterials are Effective Against Resistant Pathogens? A Comprehensive Review of the Literature.

Siraj E, Yayehrad A, Belete A Int J Nanomedicine. 2023; 18:5289-5307.

PMID: 37732155 PMC: 10508284. DOI: 10.2147/IJN.S418588.

Targeted delivery of a short antimicrobial peptide (CM11) against Helicobacter pylori gastric infection using concanavalin A-coated chitosan nanoparticles.

Moosazadeh Moghaddam M, Bolouri S, Golmohammadi R, Fasihi-Ramandi M, Heiat M, Mirnejad R J Mater Sci Mater Med. 2023; 34(9):44.

PMID: 37650975 PMC: 10471652. DOI: 10.1007/s10856-023-06748-w.

Rational Use of Ceftriaxone in Necrotizing Fasciitis and Mortality Associated with Bloodstream Infection and Hemorrhagic Bullous Lesions.

Chen H, Huang T, Chen J, Kuo L, Huang K, Tsai Y Antibiotics (Basel). 2022; 11(11).

PMID: 36358109 PMC: 9686534. DOI: 10.3390/antibiotics11111454.

Synthesis and In Vitro/Ex Vivo Characterizations of Ceftriaxone-Loaded Sodium Alginate/poly(vinyl alcohol) Clay Reinforced Nanocomposites: Possible Applications in Wound Healing.

Bibi S, Mir S, Rehman W, Menaa F, Gul A, Alaryani F Materials (Basel). 2022; 15(11).

PMID: 35683183 PMC: 9182010. DOI: 10.3390/ma15113885.

Cefotaxime Mediated Synthesis of Gold Nanoparticles: Characterization and Antibacterial Activity.

Al Hagbani T, Danish Rizvi S, Hussain T, Mehmood K, Rafi Z, Moin A Polymers (Basel). 2022; 14(4).

PMID: 35215685 PMC: 8875691. DOI: 10.3390/polym14040771.

References

Pelgrift R, Friedman A . Nanotechnology as a therapeutic tool to combat microbial resistance. Adv Drug Deliv Rev. 2013; 65(13-14):1803-15. DOI: 10.1016/j.addr.2013.07.011. View

Hrvatin V . Combating antibiotic resistance: New drugs or alternative therapies?. CMAJ. 2017; 189(37):E1199. PMC: 5602506. DOI: 10.1503/cmaj.109-5469. View

Akbarzadeh A, Samiei M, Davaran S . Magnetic nanoparticles: preparation, physical properties, and applications in biomedicine. Nanoscale Res Lett. 2012; 7(1):144. PMC: 3312841. DOI: 10.1186/1556-276X-7-144. View

Tanaka M, Nakayama H, Huruya K, Konomi I, Irie S, Kanayama A . Analysis of mutations within multiple genes associated with resistance in a clinical isolate of Neisseria gonorrhoeae with reduced ceftriaxone susceptibility that shows a multidrug-resistant phenotype. Int J Antimicrob Agents. 2005; 27(1):20-6. DOI: 10.1016/j.ijantimicag.2005.08.021. View

Gong Z, Lai W, Liu M, Hua Z, Sun Y, Xu Q . Novel Genes Related to Ceftriaxone Resistance Found among Ceftriaxone-Resistant Neisseria gonorrhoeae Strains Selected In Vitro. Antimicrob Agents Chemother. 2016; 60(4):2043-51. PMC: 4808169. DOI: 10.1128/AAC.00149-15. View

Teixeira M, Carbone C, Sousa M, Espina M, Garcia M, Sanchez-Lopez E . Nanomedicines for the Delivery of Antimicrobial Peptides (AMPs). Nanomaterials (Basel). 2020; 10(3). PMC: 7153398. DOI: 10.3390/nano10030560. View

Veiseh O, Gunn J, Zhang M . Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging. Adv Drug Deliv Rev. 2009; 62(3):284-304. PMC: 2827645. DOI: 10.1016/j.addr.2009.11.002. View

Singh A, Neupane Y, Panda B, Kohli K . Lipid Based nanoformulation of lycopene improves oral delivery: formulation optimization, ex vivo assessment and its efficacy against breast cancer. J Microencapsul. 2017; 34(4):416-429. DOI: 10.1080/02652048.2017.1340355. View

Zhao F, Yang H, Bi D, Khaledi A, Qiao M . A systematic review and meta-analysis of antibiotic resistance patterns, and the correlation between biofilm formation with virulence factors in uropathogenic E. coli isolated from urinary tract infections. Microb Pathog. 2020; 144:104196. DOI: 10.1016/j.micpath.2020.104196. View

10.

Namivandi-Zangeneh R, Sadrearhami Z, Bagheri A, Sauvage-Nguyen M, Ho K, Kumar N . Nitric Oxide-Loaded Antimicrobial Polymer for the Synergistic Eradication of Bacterial Biofilm. ACS Macro Lett. 2022; 7(5):592-597. DOI: 10.1021/acsmacrolett.8b00190. View

11.

Namivandi-Zangeneh R, Yang Y, Xu S, Wong E, Boyer C . Antibiofilm Platform based on the Combination of Antimicrobial Polymers and Essential Oils. Biomacromolecules. 2019; 21(1):262-272. DOI: 10.1021/acs.biomac.9b01278. View

12.

Yang W, Chan O, Wu T, Chen C, Su L, Chiu C . Development of ceftriaxone resistance in Salmonella enterica serotype Oranienburg during therapy for bacteremia. J Microbiol Immunol Infect. 2014; 49(1):41-5. DOI: 10.1016/j.jmii.2014.01.011. View

13.

Nakayama S, Shimuta K, Furubayashi K, Kawahata T, Unemo M, Ohnishi M . New Ceftriaxone- and Multidrug-Resistant Neisseria gonorrhoeae Strain with a Novel Mosaic penA Gene Isolated in Japan. Antimicrob Agents Chemother. 2016; 60(7):4339-41. PMC: 4914677. DOI: 10.1128/AAC.00504-16. View

14.

Szilagyi I . Layered Double Hydroxide-Based Nanomaterials-From Fundamentals to Applications. Nanomaterials (Basel). 2019; 9(8). PMC: 6724089. DOI: 10.3390/nano9081174. View

15.

Chua K, Stewardson A . Individual and community predictors of urinary ceftriaxone-resistant isolates, Victoria, Australia. Antimicrob Resist Infect Control. 2019; 8:36. PMC: 6373108. DOI: 10.1186/s13756-019-0492-8. View

16.

Morones J, Elechiguerra J, Camacho A, Holt K, Kouri J, Tapia Ramirez J . The bactericidal effect of silver nanoparticles. Nanotechnology. 2010; 16(10):2346-53. DOI: 10.1088/0957-4484/16/10/059. View

17.

Zaki N, Hafez M . Enhanced antibacterial effect of ceftriaxone sodium-loaded chitosan nanoparticles against intracellular Salmonella typhimurium. AAPS PharmSciTech. 2012; 13(2):411-21. PMC: 3364366. DOI: 10.1208/s12249-012-9758-7. View

18.

Rai M, Paralikar P, Jogee P, Agarkar G, Ingle A, Derita M . Synergistic antimicrobial potential of essential oils in combination with nanoparticles: Emerging trends and future perspectives. Int J Pharm. 2017; 519(1-2):67-78. DOI: 10.1016/j.ijpharm.2017.01.013. View

19.

Lee C, Cho I, Jeong B, Lee S . Strategies to minimize antibiotic resistance. Int J Environ Res Public Health. 2013; 10(9):4274-305. PMC: 3799537. DOI: 10.3390/ijerph10094274. View

20.

Tewabe A, Marew T, Birhanu G . The contribution of nano-based strategies in overcoming ceftriaxone resistance: a literature review. Pharmacol Res Perspect. 2021; 9(4):e00849. PMC: 8324973. DOI: 10.1002/prp2.849. View