The Uprising of Mitochondrial DNA Biomarker in Cancer

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2021 Jul 30

PMID 34326906

Citations 11

Authors

Siti Zulaikha Nashwa Mohd Khair

Siti Muslihah Abd Radzak

Abdul Aziz Mohamed Yusoff

Affiliations

Soon will be listed here.

Abstract

Cancer is a heterogeneous group of diseases, the progression of which demands an accumulation of genetic mutations and epigenetic alterations of the human nuclear genome or possibly in the mitochondrial genome as well. Despite modern diagnostic and therapeutic approaches to battle cancer, there are still serious concerns about the increase in death from cancer globally. Recently, a growing number of researchers have extensively focused on the burgeoning area of biomarkers development research, especially in noninvasive early cancer detection. Intergenomic cross talk has triggered researchers to expand their studies from nuclear genome-based cancer researches, shifting into the mitochondria-mediated associations with carcinogenesis. Thus, it leads to the discoveries of established and potential mitochondrial biomarkers with high specificity and sensitivity. The research field of mitochondrial DNA (mtDNA) biomarkers has the great potential to confer vast benefits for cancer therapeutics and patients in the future. This review seeks to summarize the comprehensive insights of nuclear genome cancer biomarkers and their usage in clinical practices, the intergenomic cross talk researches that linked mitochondrial dysfunction to carcinogenesis, and the current progress of mitochondrial cancer biomarker studies and development.

Citing Articles

Mitochondrial DNA copy number alterations: Key players in the complexity of glioblastoma (Review).

Yusoff A, Mohd Khair S, Abd Radzak S Mol Med Rep. 2025; 31(3).

PMID: 39886971 PMC: 11795256. DOI: 10.3892/mmr.2025.13443.

GDF-15 and mtDNA Deletions Are Useful Biomarkers of Mitochondrial Dysfunction in Insulin Resistance and PCOS.

Varhegyi V, Modos A, Trager D, Gerszi D, Horvath E, Sipos M Int J Mol Sci. 2024; 25(20).

PMID: 39456699 PMC: 11507876. DOI: 10.3390/ijms252010916.

Emerging Paradigms in Cancer Metastasis: Ghost Mitochondria, Vasculogenic Mimicry, and Polyploid Giant Cancer Cells.

Krotofil M, Tota M, Siednienko J, Donizy P Cancers (Basel). 2024; 16(20).

PMID: 39456632 PMC: 11506636. DOI: 10.3390/cancers16203539.

The effect of somatic mutations in mitochondrial DNA on the survival of patients with primary brain tumors.

Mohd Khair S, Ab Radzak S, Idris Z, Mat Zin A, Wan Ahmad W, Yusoff A Croat Med J. 2024; 65(2):111-121.

PMID: 38706237 PMC: 11074945.

The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation.

Ibragimova M, Kussainova A, Aripova A, Bersimbaev R, Bulgakova O Cells. 2024; 13(6.

PMID: 38534394 PMC: 10969416. DOI: 10.3390/cells13060550.

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