A Comprehensive Overview of Mitochondrial DNA 4977-bp Deletion in Cancer Studies

Overview

Journal Oncol Rev

Specialty Oncology

Date 2019 May 3

PMID 31044027

Citations 22

Authors

Abdul Aziz Mohamed Yusoff

Wan Salihah Wan Abdullah

Siti Zulaikha Nashwa Mohd Khair

Siti Muslihah Abd Radzak

Affiliations

Soon will be listed here.

Abstract

Mitochondria are cellular machines essential for energy production. The biogenesis of mitochondria is a highly complex and it depends on the coordination of the nuclear and mitochondrial genome. Mitochondrial DNA (mtDNA) mutations and deletions are suspected to be associated with carcinogenesis. The most described mtDNA deletion in various human cancers is called the 4977-bp common deletion (mDNA) and it has been explored since two decades. In spite of that, its implication in carcinogenesis still unknown and its predictive and prognostic impact remains controversial. This review article provides an overview of some of the cellular and molecular mechanisms underlying mDNA formation and a detailed summary about mDNA reported in various types of cancers. The current knowledges of mDNA as a prognostic and predictive marker are also discussed.

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