Response: Commentary: An Pipeline Identifying an HLA-A*02:01+ KRAS G12V+ Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer Patients

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Jul 30

PMID 34326838

Citations 7

Authors

Michele Mishto

Guillermo Rodriguez-Hernandez

Jacques Neefjes

Henning Urlaub

Juliane Liepe

Affiliations

Soon will be listed here.

Citing Articles

Protein degradation by human 20S proteasomes elucidates the interplay between peptide hydrolysis and splicing.

Soh W, Roetschke H, Cormican J, Teo B, Chiam N, Raabe M Nat Commun. 2024; 15(1):1147.

PMID: 38326304 PMC: 10850103. DOI: 10.1038/s41467-024-45339-3.

InvitroSPI and a large database of proteasome-generated spliced and non-spliced peptides.

Roetschke H, Rodriguez-Hernandez G, Cormican J, Yang X, Lynham S, Mishto M Sci Data. 2023; 10(1):18.

PMID: 36627305 PMC: 9832164. DOI: 10.1038/s41597-022-01890-6.

Predicting the Success of Fmoc-Based Peptide Synthesis.

Gutman I, Gutman R, Sidney J, Chihab L, Mishto M, Liepe J ACS Omega. 2022; 7(27):23771-23781.

PMID: 35847273 PMC: 9280948. DOI: 10.1021/acsomega.2c02425.

Neo-Splicetopes in Tumor Therapy: A Lost Case?.

Kloetzel P Front Immunol. 2022; 13:849863.

PMID: 35265089 PMC: 8898901. DOI: 10.3389/fimmu.2022.849863.

Database search engines and target database features impinge upon the identification of post-translationally cis-spliced peptides in HLA class I immunopeptidomes.

Mishto M, Horokhovskyi Y, Cormican J, Yang X, Lynham S, Urlaub H Proteomics. 2022; 22(10):e2100226.

PMID: 35184383 PMC: 9286349. DOI: 10.1002/pmic.202100226.

References

Liepe J, Marino F, Sidney J, Jeko A, Bunting D, Sette A . A large fraction of HLA class I ligands are proteasome-generated spliced peptides. Science. 2016; 354(6310):354-358. DOI: 10.1126/science.aaf4384. View

Kuckelkorn U, Stubler S, Textoris-Taube K, Kilian C, Niewienda A, Henklein P . Proteolytic dynamics of human 20S thymoproteasome. J Biol Chem. 2019; 294(19):7740-7754. PMC: 6514615. DOI: 10.1074/jbc.RA118.007347. View

Vigneron N, Stroobant V, Chapiro J, Ooms A, Degiovanni G, Morel S . An antigenic peptide produced by peptide splicing in the proteasome. Science. 2004; 304(5670):587-90. DOI: 10.1126/science.1095522. View

Ebstein F, Textoris-Taube K, Keller C, Golnik R, Vigneron N, Van den Eynde B . Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes. Sci Rep. 2016; 6:24032. PMC: 4822137. DOI: 10.1038/srep24032. View

Mishto M, Goede A, Taube K, Keller C, Janek K, Henklein P . Driving forces of proteasome-catalyzed peptide splicing in yeast and humans. Mol Cell Proteomics. 2012; 11(10):1008-23. PMC: 3494140. DOI: 10.1074/mcp.M112.020164. View

Liepe J, Holzhutter H, Bellavista E, Kloetzel P, Stumpf M, Mishto M . Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes. Elife. 2015; 4:e07545. PMC: 4611054. DOI: 10.7554/eLife.07545. View

Mansurkhodzhaev A, Barbosa C, Mishto M, Liepe J . Proteasome-Generated -Spliced Peptides and Their Potential Role in CD8 T Cell Tolerance. Front Immunol. 2021; 12:614276. PMC: 7943738. DOI: 10.3389/fimmu.2021.614276. View

Shin S, Choi D, Jung K, Bae J, Kim J, Park S . Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration. Nat Commun. 2017; 8:15090. PMC: 5436137. DOI: 10.1038/ncomms15090. View

Dianzani C, Bellavista E, Liepe J, Verderio C, Martucci M, Santoro A . Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis. Sci Rep. 2017; 7:43718. PMC: 5343429. DOI: 10.1038/srep43718. View

10.

Dianzani C, Vecchio D, Clemente N, Chiocchetti A, Boneschi F, Galimberti D . Untangling Extracellular Proteasome-Osteopontin Circuit Dynamics in Multiple Sclerosis. Cells. 2019; 8(3). PMC: 6468732. DOI: 10.3390/cells8030262. View

11.

Dalet A, Robbins P, Stroobant V, Vigneron N, Li Y, El-Gamil M . An antigenic peptide produced by reverse splicing and double asparagine deamidation. Proc Natl Acad Sci U S A. 2011; 108(29):E323-31. PMC: 3142003. DOI: 10.1073/pnas.1101892108. View

12.

Berkers C, de Jong A, Schuurman K, Linnemann C, Meiring H, Janssen L . Definition of Proteasomal Peptide Splicing Rules for High-Efficiency Spliced Peptide Presentation by MHC Class I Molecules. J Immunol. 2015; 195(9):4085-95. PMC: 4642839. DOI: 10.4049/jimmunol.1402455. View

13.

Mishto M . What We See, What We Do Not See, and What We Do Not Want to See in HLA Class I Immunopeptidomes. Proteomics. 2020; 20(15-16):e2000112. DOI: 10.1002/pmic.202000112. View

14.

Schmidtke G, Emch S, Groettrup M, Holzhutter H . Evidence for the existence of a non-catalytic modifier site of peptide hydrolysis by the 20 S proteasome. J Biol Chem. 2000; 275(29):22056-63. DOI: 10.1074/jbc.M002513200. View

15.

Berkers C, de Jong A, Ovaa H, Rodenko B . Transpeptidation and reverse proteolysis and their consequences for immunity. Int J Biochem Cell Biol. 2008; 41(1):66-71. DOI: 10.1016/j.biocel.2008.08.036. View

16.

Paes W, Leonov G, Partridge T, Chikata T, Murakoshi H, Frangou A . Contribution of proteasome-catalyzed peptide -splicing to viral targeting by CD8 T cells in HIV-1 infection. Proc Natl Acad Sci U S A. 2019; 116(49):24748-24759. PMC: 6900506. DOI: 10.1073/pnas.1911622116. View

17.

Liepe J, Ovaa H, Mishto M . Why do proteases mess up with antigen presentation by re-shuffling antigen sequences?. Curr Opin Immunol. 2018; 52:81-86. DOI: 10.1016/j.coi.2018.04.016. View

18.

Tran E, Robbins P, Lu Y, Prickett T, Gartner J, Jia L . T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer. N Engl J Med. 2016; 375(23):2255-2262. PMC: 5178827. DOI: 10.1056/NEJMoa1609279. View

19.

Gonzalez-Duque S, Azoury M, Colli M, Afonso G, Turatsinze J, Nigi L . Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors. Cell Metab. 2018; 28(6):946-960.e6. DOI: 10.1016/j.cmet.2018.07.007. View

20.

Faridi P, Woods K, Ostrouska S, Deceneux C, Aranha R, Duscharla D . Spliced Peptides and Cytokine-Driven Changes in the Immunopeptidome of Melanoma. Cancer Immunol Res. 2020; 8(10):1322-1334. DOI: 10.1158/2326-6066.CIR-19-0894. View