Manipulating the Exposome to Enable Better Ageing

Overview

Journal Biochem J

Specialty Biochemistry

Date 2021 Jul 28

PMID 34319404

Citations 14

Authors

Paul G Shiels

Johanna Painer

Barbara Natterson-Horowitz

Richard J Johnson

Jaime J Miranda

Peter Stenvinkel

Affiliations

Soon will be listed here.

Abstract

The sum total of life course exposures creates an exposome that has a significant impact on age-related health. Understanding the interplay between exposome factors and the (epi) genome, offers pertinent insights into the ageing process and its relationship with the accumulation of allostatic load. We propose to exploit this to develop a biomimetic approach that will provide insight into how evolution through natural selection in other species has solved many age related human health issues. In particular, we will emphasise the need to reconnect a more mechanistic approach to medical science with a broader natural sciences approach, using biomimetics to mitigate the global burden of age related ill health. In particular, we will discuss how such an approach indicates leverage of the activities of the Nrf 2 gene to enhance health span via reintroduction of the classical 'Food as Medicine' concept, including modulation of the microbiome and the creation of more salutogenic and biophilic environments. Additionally, we will discuss how this approach integrates with novel and developing senotherapies.

Citing Articles

Harnessing Evolution and Biomimetics to Enhance Planetary Health: Kidney Insights.

Stenvinkel P, Shiels P, Kotanko P, Evenepoel P, Johnson R J Am Soc Nephrol. 2024; 36(2):311-321.

PMID: 39607684 PMC: 11801751. DOI: 10.1681/ASN.0000000582.

Stay social, stay young: a bioanthropological outlook on the processes linking sociality and ageing.

Iannuzzi V, Narboux-Neme N, Lehoczki A, Levi G, Giuliani C Geroscience. 2024; 47(1):721-744.

PMID: 39527178 PMC: 11872968. DOI: 10.1007/s11357-024-01416-5.

Gerotherapeutics: aging mechanism-based pharmaceutical and behavioral interventions to reduce cancer racial and ethnic disparities.

Mandelblatt J, Antoni M, Bethea T, Cole S, Hudson B, Penedo F J Natl Cancer Inst. 2024; 117(3):406-422.

PMID: 39196709 PMC: 11884862. DOI: 10.1093/jnci/djae211.

Quantum healthy longevity from cells to cities.

Woods T, Palmarini N, Corner L, Siow R Front Aging. 2024; 5:1416447.

PMID: 39193426 PMC: 11347422. DOI: 10.3389/fragi.2024.1416447.

Pathological mechanisms of kidney disease in ageing.

Yamamoto T, Isaka Y Nat Rev Nephrol. 2024; 20(9):603-615.

PMID: 39025993 DOI: 10.1038/s41581-024-00868-4.

References

Ma S, Lee S, Kim E, Park T, Seluanov A, Gorbunova V . Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. Cell Rep. 2015; 13(7):1319-1326. PMC: 4771060. DOI: 10.1016/j.celrep.2015.10.014. View

Haines A, Ebi K . The Imperative for Climate Action to Protect Health. N Engl J Med. 2019; 380(3):263-273. DOI: 10.1056/NEJMra1807873. View

Rojas-Rueda D, Nieuwenhuijsen M, Gascon M, Perez-Leon D, Mudu P . Green spaces and mortality: a systematic review and meta-analysis of cohort studies. Lancet Planet Health. 2019; 3(11):e469-e477. PMC: 6873641. DOI: 10.1016/S2542-5196(19)30215-3. View

Horton R, Beaglehole R, Bonita R, Raeburn J, Mckee M, Wall S . From public to planetary health: a manifesto. Lancet. 2014; 383(9920):847. DOI: 10.1016/S0140-6736(14)60409-8. View

Horvath S . DNA methylation age of human tissues and cell types. Genome Biol. 2013; 14(10):R115. PMC: 4015143. DOI: 10.1186/gb-2013-14-10-r115. View

Ghosh T, Rampelli S, Jeffery I, Santoro A, Neto M, Capri M . Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries. Gut. 2020; 69(7):1218-1228. PMC: 7306987. DOI: 10.1136/gutjnl-2019-319654. View

Johnson R, Sanchez-Lozada L, Newman L, Lanaspa M, Diaz H, Lemery J . Climate Change and the Kidney. Ann Nutr Metab. 2019; 74 Suppl 3:38-44. DOI: 10.1159/000500344. View

Astell-Burt T, Feng X . Urban green space, tree canopy and prevention of cardiometabolic diseases: a multilevel longitudinal study of 46 786 Australians. Int J Epidemiol. 2019; 49(3):926-933. PMC: 7394941. DOI: 10.1093/ije/dyz239. View

Marton A, Kaneko T, Kovalik J, Yasui A, Nishiyama A, Kitada K . Organ protection by SGLT2 inhibitors: role of metabolic energy and water conservation. Nat Rev Nephrol. 2020; 17(1):65-77. DOI: 10.1038/s41581-020-00350-x. View

10.

Stenvinkel P, Painer J, Kuro-O M, Lanaspa M, Arnold W, Ruf T . Novel treatment strategies for chronic kidney disease: insights from the animal kingdom. Nat Rev Nephrol. 2018; 14(4):265-284. DOI: 10.1038/nrneph.2017.169. View

11.

Ma S, Yim S, Lee S, Kim E, Lee S, Chang K . Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity. Cell Metab. 2015; 22(2):332-43. PMC: 4758382. DOI: 10.1016/j.cmet.2015.07.005. View

12.

OToole P, Shiels P . The role of the microbiota in sedentary lifestyle disorders and ageing: lessons from the animal kingdom. J Intern Med. 2020; 287(3):271-282. DOI: 10.1111/joim.13021. View

13.

Yang B, Markevych I, Bloom M, Heinrich J, Guo Y, Morawska L . Community greenness, blood pressure, and hypertension in urban dwellers: The 33 Communities Chinese Health Study. Environ Int. 2019; 126:727-734. DOI: 10.1016/j.envint.2019.02.068. View

14.

Lopez-Otin C, Blasco M, Partridge L, Serrano M, Kroemer G . The hallmarks of aging. Cell. 2013; 153(6):1194-217. PMC: 3836174. DOI: 10.1016/j.cell.2013.05.039. View

15.

Garcia-Arroyo F, Gonzaga-Sanchez G, Tapia E, Munoz-Jimenez I, Manterola-Romero L, Osorio-Alonso H . Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a High-Fat/High-Sugar Diet. Int J Mol Sci. 2021; 22(5). PMC: 7957708. DOI: 10.3390/ijms22052431. View

16.

Stenvinkel P, Meyer C, Block G, Chertow G, Shiels P . Understanding the role of the cytoprotective transcription factor nuclear factor erythroid 2-related factor 2-lessons from evolution, the animal kingdom and rare progeroid syndromes. Nephrol Dial Transplant. 2019; 35(12):2036-2045. PMC: 7716811. DOI: 10.1093/ndt/gfz120. View

17.

Stenvinkel P, Shiels P . Long-lived animals with negligible senescence: clues for ageing research. Biochem Soc Trans. 2019; 47(4):1157-1164. DOI: 10.1042/BST20190105. View

18.

Yin Q, Zhu L, Liu D, Irwin D, Zhang S, Pan Y . Molecular Evolution of the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene Nrf2 in Old World Fruit Bats (Chiroptera: Pteropodidae). PLoS One. 2016; 11(1):e0146274. PMC: 4703304. DOI: 10.1371/journal.pone.0146274. View

19.

Levine M, Lu A, Quach A, Chen B, Assimes T, Bandinelli S . An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY). 2018; 10(4):573-591. PMC: 5940111. DOI: 10.18632/aging.101414. View

20.

Dzhambov A, Markevych I, Lercher P . Greenspace seems protective of both high and low blood pressure among residents of an Alpine valley. Environ Int. 2018; 121(Pt 1):443-452. DOI: 10.1016/j.envint.2018.09.044. View