What Can the Gut Microbiota of Animals Teach Us About the Relationship Between Nutrition and Burden of Lifestyle Diseases?

Overview

Journal Nutrients

Date 2024 Jun 19

PMID 38892721

Authors

Denise Mafra

Natalia A Borges

Beatriz G Baptista

Layla F Martins

Gillian Borland

Paul G Shiels

Peter Stenvinkel

Affiliations

Soon will be listed here.

Abstract

The gut microbiota performs several crucial roles in a holobiont with its host, including immune regulation, nutrient absorption, synthesis, and defense against external pathogens, significantly influencing host physiology. Disruption of the gut microbiota has been linked to various chronic conditions, including cardiovascular, kidney, liver, respiratory, and intestinal diseases. Studying how animals adapt their gut microbiota across their life course at different life stages and under the dynamics of extreme environmental conditions can provide valuable insights from the natural world into how the microbiota modulates host biology, with a view to translating these into treatments or preventative measures for human diseases. By modulating the gut microbiota, opportunities to address many complications associated with chronic diseases appear. Such a biomimetic approach holds promise for exploring new strategies in healthcare and disease management.

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References

Ziegler M, Seneca F, Yum L, Palumbi S, Voolstra C . Bacterial community dynamics are linked to patterns of coral heat tolerance. Nat Commun. 2017; 8:14213. PMC: 5309854. DOI: 10.1038/ncomms14213. View

Moran N, Yun Y . Experimental replacement of an obligate insect symbiont. Proc Natl Acad Sci U S A. 2015; 112(7):2093-6. PMC: 4343100. DOI: 10.1073/pnas.1420037112. View

Reshef L, Koren O, Loya Y, Zilber-Rosenberg I, Rosenberg E . The coral probiotic hypothesis. Environ Microbiol. 2006; 8(12):2068-73. DOI: 10.1111/j.1462-2920.2006.01148.x. View

Zhao S, Lin L, Kan G, Xu C, Tang Q, Yu C . High autophagy in the naked mole rat may play a significant role in maintaining good health. Cell Physiol Biochem. 2014; 33(2):321-32. DOI: 10.1159/000356672. View

Chua K, Fatima I, Lau Y, Hong K, Yin W, Mardaryev A . Bacterial microbiome of faecal samples of naked mole-rat collected from the toilet chamber. BMC Res Notes. 2022; 15(1):107. PMC: 8932300. DOI: 10.1186/s13104-022-06000-8. View

Olukomaiya O, Fernando C, Mereddy R, Li X, Sultanbawa Y . Solid-state fermented plant protein sources in the diets of broiler chickens: A review. Anim Nutr. 2020; 5(4):319-330. PMC: 6920459. DOI: 10.1016/j.aninu.2019.05.005. View

Goodrich J, Davenport E, Beaumont M, Jackson M, Knight R, Ober C . Genetic Determinants of the Gut Microbiome in UK Twins. Cell Host Microbe. 2016; 19(5):731-43. PMC: 4915943. DOI: 10.1016/j.chom.2016.04.017. View

Stenvinkel P, Painer J, Kuro-O M, Lanaspa M, Arnold W, Ruf T . Novel treatment strategies for chronic kidney disease: insights from the animal kingdom. Nat Rev Nephrol. 2018; 14(4):265-284. DOI: 10.1038/nrneph.2017.169. View

Cong W, Xing J, Feng Y, Wang J, Fu R, Yue B . The microbiota in the intestinal and respiratory tracts of naked mole-rats revealed by high-throughput sequencing. BMC Microbiol. 2018; 18(1):89. PMC: 6103993. DOI: 10.1186/s12866-018-1226-4. View

10.

Liu X, Yu J, Huan Z, Xu M, Song T, Yang R . Comparing the gut microbiota of Sichuan golden monkeys across multiple captive and wild settings: roles of anthropogenic activities and host factors. BMC Genomics. 2024; 25(1):148. PMC: 10848473. DOI: 10.1186/s12864-024-10041-7. View

11.

Zhang W, Liu W, Hou R, Zhang L, Schmitz-Esser S, Sun H . Age-associated microbiome shows the giant panda lives on hemicelluloses, not on cellulose. ISME J. 2018; 12(5):1319-1328. PMC: 5931968. DOI: 10.1038/s41396-018-0051-y. View

12.

Elbanna K, El Hadad S, Assaeedi A, Aldahlawi A, Khider M, Alhebshi A . In vitro and in vivo evidences for innate immune stimulators lactic acid bacterial starters isolated from fermented camel dairy products. Sci Rep. 2018; 8(1):12553. PMC: 6105719. DOI: 10.1038/s41598-018-31006-3. View

13.

Przybylo M, Hummel J, Ortmann S, Codron D, Kohlschein G, Kilga D . Digesta passage in nondomestic ruminants: Separation mechanisms in 'moose-type' and 'cattle-type' species, and seemingly atypical browsers. Comp Biochem Physiol A Mol Integr Physiol. 2019; 235:180-192. DOI: 10.1016/j.cbpa.2019.06.010. View

14.

Cho H, Soundrarajan N, Le Van Chanh Q, Jeon H, Cha S, Kang M . The novel cathelicidin of naked mole rats, Hg-CATH, showed potent antimicrobial activity and low cytotoxicity. Gene. 2018; 676:164-170. DOI: 10.1016/j.gene.2018.07.005. View

15.

Carter M, Olm M, Merrill B, Dahan D, Tripathi S, Spencer S . Ultra-deep sequencing of Hadza hunter-gatherers recovers vanishing gut microbes. Cell. 2023; 186(14):3111-3124.e13. PMC: 10330870. DOI: 10.1016/j.cell.2023.05.046. View

16.

Cuyper A, Meloro C, Abraham A, Muller D, Codron D, Janssens G . The uneven weight distribution between predators and prey: Comparing gut fill between terrestrial herbivores and carnivores. Comp Biochem Physiol A Mol Integr Physiol. 2020; 243:110683. DOI: 10.1016/j.cbpa.2020.110683. View

17.

OToole P, Shiels P . The role of the microbiota in sedentary lifestyle disorders and ageing: lessons from the animal kingdom. J Intern Med. 2020; 287(3):271-282. DOI: 10.1111/joim.13021. View

18.

Millette J, Sauther M, Cuozzo F, Ness J . The impact of dental impairment on ring-tailed lemur food processing performance. Am J Phys Anthropol. 2012; 148(2):238-48. DOI: 10.1002/ajpa.21571. View

19.

Moustafa M, Chel H, Thu M, Bawm S, Htun L, Win M . Anthropogenic interferences lead to gut microbiome dysbiosis in Asian elephants and may alter adaptation processes to surrounding environments. Sci Rep. 2021; 11(1):741. PMC: 7803949. DOI: 10.1038/s41598-020-80537-1. View

20.

Stenvinkel P, Meyer C, Block G, Chertow G, Shiels P . Understanding the role of the cytoprotective transcription factor nuclear factor erythroid 2-related factor 2-lessons from evolution, the animal kingdom and rare progeroid syndromes. Nephrol Dial Transplant. 2019; 35(12):2036-2045. PMC: 7716811. DOI: 10.1093/ndt/gfz120. View