Biochanin A Inhibits Glioblastoma Growth Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Jul 26

PMID 34307130

Citations 4

Authors

Qiang Dong

Qiao Li

Lei Duan

Hang Yin

Xiaoqing Wang

Yang Liu

Bo Wang

Kun Li

Xuan Yao

Guoqiang Yuan

Yawen Pan

Affiliations

Soon will be listed here.

Abstract

Abnormal metabolism serves a critical role in glioblastoma (GBM). Biochanin A (BCA), a flavonoid phenolic compound found in edible and herbal plants, has antioxidative and antitumor activities. However, it remains unclear whether BCA has an effect on energy metabolism. The aim of the present study was to evaluate the anticancer effects and molecular mechanism of the effect of BCA on energy metabolism. We observed that BCA inhibited the growth of U251 cells by the mitochondria-mediated intrinsic apoptotic pathway. BCA treatment reduced metabolic function, repressed mitochondrial membrane potential, and increased the production of reactive oxygen species (ROS) in GBM. In addition, we found that BCA decreased aerobic glycolysis by inactivation of the AKT/mTOR pathway. Taken together, the results demonstrate that treatment with BCA inhibited the proliferation of GBM by regulating metabolic reprogramming.

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