Mitochondrial DNA 4977 Bp Deletion in Peripheral Blood Is Associated With Polycystic Ovary Syndrome

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2021 Jul 26

PMID 34305813

Citations 5

Authors

Mujin Ye

Bin Hu

Weihui Shi

Fei Guo

Chenming Xu

Shuyuan Li

Affiliations

Soon will be listed here.

Abstract

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder worldwide. We aimed to examine the associations of two mitochondrial DNA (mtDNA) biomarkers in the peripheral blood, mtDNA copy number (CN), and mtDNA deletion rate (DR), with PCOS in a clinical setting.

Methods: We performed a study involving 263 women with PCOS and 326 age-matched controls between June 2015 and June 2019. The mtDNA CN and mtDNA DR were measured using multiplex probe-based qPCR. The associations of the mtDNA CN and mtDNA DR with the risk of PCOS were estimated using logistic regression.

Results: Analysis of the associations between mtDNA biomarkers and PCOS indicate that the mtDNA CN ( = 0.003) and mtDNA DR ( < 0.001) in PCOS patients were significantly higher than those in the controls. After adjusting for the body mass index, luteinizing hormone/follicle-stimulating hormone ratio, and testosterone level, only higher mtDNA DR was associated with PCOS (odds ratio 1.053, 95% confidence interval 1.024 to 1.083; < 0.001). The linear dose-response trends of the mtDNA DR were also supported by the quartile analysis.

Conclusion: Multivariable models suggest that mtDNA DR levels are strongly associated with PCOS and represent an independent risk factor for PCOS. Further investigation of the utility of mtDNA as a biomarker for PCOS is warranted.

Citing Articles

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Are Women with Polycystic Ovary Syndrome at Increased Risk of Alzheimer Disease? Lessons from Insulin Resistance, Tryptophan and Gonadotropin Disturbances and Their Link with Amyloid-Beta Aggregation.

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Siemers K, Klein A, Baack M Int J Mol Sci. 2023; 24(17).

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Yan M, Wang Y, Wang Z, Liu X, Yang Y, Duan X J Endocr Soc. 2023; 7(5):bvad034.

PMID: 36936714 PMC: 10016062. DOI: 10.1210/jendso/bvad034.

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