The Cardiovascular Effects of Hydrogen Sulfide: The Epigenetic Mechanisms

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2021 Jul 24

PMID 34302693

Citations 1

Authors

Qian Ding

Yi-Zhun Zhu

Affiliations

Soon will be listed here.

Abstract

Hydrogen sulfide (HS), known as a gas signal molecule, plays an important role in the development of cardiovascular diseases (CVD) through mechanisms such as angiogenesis, vasodilation, and anti-vascular endothelial cell senescence. Current studies have shown that HS can regulate cardiac function through epigenetic regulation. The regulation has opened up a new avenue for the study of CVD development mechanism and HS related drug discoveries.

Citing Articles

Role of hydrogen sulphide in physiological and pathological angiogenesis.

Zhang Y, Jing M, Cai C, Zhu S, Zhang C, Wang Q Cell Prolif. 2022; 56(3):e13374.

PMID: 36478328 PMC: 9977675. DOI: 10.1111/cpr.13374.

References

Lorenzen J, Martino F, Thum T . Epigenetic modifications in cardiovascular disease. Basic Res Cardiol. 2012; 107(2):245. PMC: 3329881. DOI: 10.1007/s00395-012-0245-9. View

Jones M, Goodman S, Kobor M . DNA methylation and healthy human aging. Aging Cell. 2015; 14(6):924-32. PMC: 4693469. DOI: 10.1111/acel.12349. View

Mazzio E, Soliman K . Basic concepts of epigenetics: impact of environmental signals on gene expression. Epigenetics. 2012; 7(2):119-30. PMC: 3335905. DOI: 10.4161/epi.7.2.18764. View

Shefa U, Kim M, Jeong N, Jung J . Antioxidant and Cell-Signaling Functions of Hydrogen Sulfide in the Central Nervous System. Oxid Med Cell Longev. 2018; 2018:1873962. PMC: 5817206. DOI: 10.1155/2018/1873962. View

Yang G, Wu L, Jiang B, Yang W, Qi J, Cao K . H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science. 2008; 322(5901):587-90. PMC: 2749494. DOI: 10.1126/science.1162667. View

Shibuya N, Tanaka M, Yoshida M, Ogasawara Y, Togawa T, Ishii K . 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain. Antioxid Redox Signal. 2008; 11(4):703-14. DOI: 10.1089/ars.2008.2253. View

Caliendo G, Cirino G, Santagada V, Wallace J . Synthesis and biological effects of hydrogen sulfide (H2S): development of H2S-releasing drugs as pharmaceuticals. J Med Chem. 2010; 53(17):6275-86. DOI: 10.1021/jm901638j. View

Liu L, Yan L, Chen Y, Zeng G, Zhou Y, Chen H . A role for diallyl trisulfide in mitochondrial antioxidative stress contributes to its protective effects against vascular endothelial impairment. Eur J Pharmacol. 2014; 725:23-31. DOI: 10.1016/j.ejphar.2014.01.010. View

Benavides G, Squadrito G, Mills R, Patel H, Isbell T, Patel R . Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci U S A. 2007; 104(46):17977-82. PMC: 2084282. DOI: 10.1073/pnas.0705710104. View

10.

Li L, Whiteman M, Guan Y, Neo K, Cheng Y, Lee S . Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide. Circulation. 2008; 117(18):2351-60. DOI: 10.1161/CIRCULATIONAHA.107.753467. View

11.

Powell C, Dillon K, Matson J . A review of hydrogen sulfide (HS) donors: Chemistry and potential therapeutic applications. Biochem Pharmacol. 2017; 149:110-123. PMC: 5866188. DOI: 10.1016/j.bcp.2017.11.014. View

12.

Szczesny B, Modis K, Yanagi K, Coletta C, le Trionnaire S, Perry A . AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide. 2014; 41:120-30. PMC: 4225488. DOI: 10.1016/j.niox.2014.04.008. View

13.

Wen Y, Wang H, Zhu Y . The Drug Developments of Hydrogen Sulfide on Cardiovascular Disease. Oxid Med Cell Longev. 2018; 2018:4010395. PMC: 6087600. DOI: 10.1155/2018/4010395. View

15.

Feng S, Zhao Y, Xian M, Wang Q . Biological thiols-triggered hydrogen sulfide releasing microfibers for tissue engineering applications. Acta Biomater. 2015; 27:205-213. PMC: 4609630. DOI: 10.1016/j.actbio.2015.09.010. View

16.

Wu J, Li Y, He C, Kang J, Ye J, Xiao Z . Novel HS Releasing Nanofibrous Coating for In Vivo Dermal Wound Regeneration. ACS Appl Mater Interfaces. 2016; 8(41):27474-27481. DOI: 10.1021/acsami.6b06466. View

18.

Sodha N, Clements R, Feng J, Liu Y, Bianchi C, Horvath E . Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia/reperfusion injury. J Thorac Cardiovasc Surg. 2009; 138(4):977-84. PMC: 2758694. DOI: 10.1016/j.jtcvs.2008.08.074. View

19.

Li L, Bhatia M, Zhu Y, Zhu Y, Ramnath R, Wang Z . Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. FASEB J. 2005; 19(9):1196-8. DOI: 10.1096/fj.04-3583fje. View

20.

Pan L, Liu X, Gong Q, Wu D, Zhu Y . Hydrogen sulfide attenuated tumor necrosis factor-α-induced inflammatory signaling and dysfunction in vascular endothelial cells. PLoS One. 2011; 6(5):e19766. PMC: 3091882. DOI: 10.1371/journal.pone.0019766. View

21.

Pan L, Liu X, Gong Q, Zhu Y . S-Propargyl-cysteine (SPRC) attenuated lipopolysaccharide-induced inflammatory response in H9c2 cells involved in a hydrogen sulfide-dependent mechanism. Amino Acids. 2011; 41(1):205-15. DOI: 10.1007/s00726-011-0834-1. View

22.

Wang M, Tang W, Xin H, Zhu Y . S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6/STAT3 Pathway. PLoS One. 2016; 11(9):e0163289. PMC: 5029915. DOI: 10.1371/journal.pone.0163289. View