Hydrogen Sulfide: a Novel Immunoinflammatory Regulator in Rheumatoid Arthritis

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2021 Jul 24

PMID 34302692

Citations 1

Authors

M Li

Jian-Chun Mao

Yi-Zhun Zhu

Affiliations

Soon will be listed here.

Abstract

Hydrogen sulfide (HS), an endogenous, gaseous, signaling transmitter, has been shown to have vasodilative, anti-oxidative, anti-inflammatory, and cytoprotective activities. Increasing evidence also indicates that HS can suppress the production of inflammatory mediators by immune cells, for example, T cells and macrophages. Inflammation is closely related to an immune response in several diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE), and cancer. Considering these biological effects of HS, a potential role in the treatment of immune-related RA is being exploited. In the present review, we will provide an overview of the therapeutic potential of HS in RA treatment.

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