Diagnostic Accuracy of Dual-phase F-FP-CIT PET Imaging for Detection and Differential Diagnosis of Parkinsonism

Overview

Journal Sci Rep

Specialty Science

Date 2021 Jul 23

PMID 34294739

Citations 6

Authors

Minyoung Oh

Narae Lee

Chanwoo Kim

Hye Joo Son

Changhwan Sung

Seung Jun Oh

Sang Ju Lee

Sun Ju Chung

Chong Sik Lee

Jae Seung Kim

Affiliations

Soon will be listed here.

Abstract

Delayed phase F-FP-CIT PET (dCIT) can assess the striatal dopamine transporter binding to detect degenerative parkinsonism (DP). Early phase F-FP-CIT (eCIT) can assess the regional brain activity for differential diagnosis among parkinsonism similar with F-FDG PET. We evaluated the diagnostic performance of dual phase F-FP-CIT PET (dual CIT) and F-FDG PET compared with clinical diagnosis in 141 subjects [36 with idiopathic Parkinson's disease (IPD), 77 with multiple system atrophy (MSA), 18 with progressive supranuclear palsy (PSP), and 10 with non-DP)]. Visual assessment of eCIT, dCIT, dual CIT, F-FDG and F-FDG PET with dCIT was in agreement with the clinical diagnosis in 61.7%, 69.5%, 95.7%, 81.6%, and 97.2% of cases, respectively. ECIT showed about 90% concordance with non-DP and MSA, and 8.3% and 27.8% with IPD and PSP, respectively. DCIT showed ≥ 88% concordance with non-DP, IPD, and PSP, and 49.4% concordance with MSA. Dual CIT showed ≥ 90% concordance in all groups. F-FDG PET showed ≥ 90% concordance with non-DP, MSA, and PSP, but only 33.3% concordance with IPD. The combination of F-FDG and dCIT yielded ≥ 90% concordance in all groups. Dual CIT may represent a powerful alternative to the combination of F-FDG PET and dCIT for differential diagnosis of parkinsonian disorders.

Citing Articles

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