16S RDNA Analysis of the Intestinal Microbes in Osteoporotic Rats

Overview

Journal Biosci Microbiota Food Health

Specialty Biology

Date 2021 Jul 21

PMID 34285861

Citations 6

Authors

Yan Sun

Hui-Jie Zhang

Ran Chen

Hong-Bin Zhao

Wen-Hui Lee

Affiliations

Soon will be listed here.

Abstract

This study aimed to reveal the differences in intestinal microbes in osteoporotic rats. The rats were divided into two groups: the control and OP (osteoporosis) groups (=6). Days 0 and 70 were set as the time points. The rats in the OP group underwent bilateral ovariectomy (OVX). Differences between the control and OP groups were determined by 16S rDNA analysis. The relative abundances of OTUs and alpha/beta diversities were determined at days 0 days and 70. The abundances of at the phylum level and , , , , , , , etc., at the genus level were found to be different between the control_70d and OP_70d groups. KEGG ontology analysis showed that the function of lipid metabolism could be related to OP. The 16S rDNA analysis in the OP rats revealed that intestinal microbes take part in the processes of OP and could affect lipid metabolism. Further study of the relationship between OP and intestinal microbes is necessary, and the prospect for intestinal microbes is a potential treatment for OP.

Citing Articles

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