Alterations in Gene Expression of Renin-Angiotensin System Components and Related Proteins in Colorectal Cancer

Overview

Journal J Renin Angiotensin Aldosterone Syst

Publisher Sage Publications

Specialty Physiology

Date 2021 Jul 21

PMID 34285715

Citations 2

Authors

Danial Mehranfard

Gabriela Perez

Andres Rodriguez

Julia M Ladna

Christopher T Neagra

Benjamin Goldstein

Timothy Carroll

Alice Tran

Malav Trivedi

Robert C Speth

Affiliations

Soon will be listed here.

Abstract

Materials And Methods: Quantitative expression of the RNA of these 17 genes in normal and cancerous tissues obtained using chip arrays from the public functional genomics data repository, Gene Expression Omnibus (GEO) application, was compared statistically.

Results: Expression of four genes, (angiotensinogen), (aminopeptidase A) (neprilysin), and (prolyl endopeptidase), was significantly upregulated in CRC specimens. Expression of (renin), (thimet oligopeptidase), (neurolysin), (prolyl carboxypeptidase), (aminopeptidase N), and (Mas receptor) was downregulated in CRC specimens.

Conclusions: Presuming gene expression parallel protein expression, these results suggest that increased production of the angiotensinogen precursor of angiotensin (ANG) peptides, with the reduction of the enzymes that metabolize it to ANG II, can lead to accumulation of angiotensinogen in CRC tissues. Downregulation of , , , and gene expression, whose proteins contribute to the ACE2/ANG 1-7/Mas axis, suggests that reduced activity of this RAS branch could be permissive for oncogenicity. Components of the RAS may be potential therapeutic targets for treatment of CRC.

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