Robert C Speth
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Explore the profile of Robert C Speth including associated specialties, affiliations and a list of published articles.
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113
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1719
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Recent Articles
1.
Warrayat A, Ali A, Waked J, Tocci D, Speth R
Trends Mol Med
. 2024 Oct;
PMID: 39438198
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic debilitating condition with no cure that shares commonality with long-COVID. This review examines current understanding of long-COVID symptoms, characteristics of the affected...
2.
Hettiarachchi S, Kwon Y, Omidi Y, Speth R
Heliyon
. 2023 Jul;
9(6):e16951.
PMID: 37484281
The renin-angiotensin system (RAS) is a hormonal cascade that contributes to several disorders: systemic hypertension, heart failure, kidney disease, and neurodegenerative disease. Activation of the RAS can promote inflammation and...
3.
Sabbir M, Swanson M, Speth R, Albensi B
Front Cell Dev Biol
. 2023 Jun;
11:1179252.
PMID: 37293125
In a previous retrospective study using postmortem human brain tissues, we demonstrated that loss of Cholinergic Receptor Muscarinic 1 (CHRM1) in the temporal cortex of a subset of Alzheimer's patients...
4.
5.
Gay M, Bell K, Bujold E, Geraci M, Lee D, Sandberg K, et al.
J Clin Transl Sci
. 2023 Feb;
6(1):e145.
PMID: 36756075
Introduction: The goal of clinical and translational science (CTS) is to fill gaps in medical knowledge toward improving human health. However, one of our most pressing challenges does not reside...
6.
Noto N, Restrepo Y, Pang H, Stoyell-Conti F, West C, Speth R
Pharmacol Res Perspect
. 2023 Jan;
11(1):e01053.
PMID: 36639940
Angiotensin II analogue and β-arrestin biased agonist TRV027 (Sarcosine , d-Alanine -Angiotensin (Ang) II; SD Ang II), developed by Trevena, Inc. in the early 2010s, brought hopes of a novel...
7.
Speth R, Bader M
Med Res Arch
. 2022 Nov;
10(9).
PMID: 36438606
Early in the COVID-19 pandemic when it was first reported that SARS-CoV-2 used membrane-bound angiotensin-converting enzyme-2 (ACE2) as its receptor for entry into cells, warnings were raised against the use...
8.
Restrepo Y, Noto N, Speth R
Clin Sci (Lond)
. 2022 Nov;
136(21):1513-1533.
PMID: 36326719
For years, the AT2R-selective ligand CGP42112 has been erroneously characterized as a partial agonist, partly due to its ability to also interact with the AT1R at high concentrations. As late...
9.
Sabbir M, Speth R, Albensi B
J Alzheimers Dis
. 2022 Sep;
90(2):727-747.
PMID: 36155524
Background: Dysfunction of cholinergic neurotransmission is a hallmark of Alzheimer's disease (AD); forming the basis for using acetylcholine (ACh) esterase (AChE) inhibitors to mitigate symptoms of ACh deficiency in AD....
10.