Biodegradation of Aromatic Pollutants Meets Synthetic Biology

Overview

Journal Synth Syst Biotechnol

Specialty Biotechnology

Date 2021 Jul 19

PMID 34278013

Citations 10

Authors

Liang Xiang

Guoqiang Li

Luan Wen

Cong Su

Yong Liu

Hongzhi Tang

Junbiao Dai

Affiliations

Soon will be listed here.

Abstract

Ubiquitously distributed microorganisms are natural decomposers of environmental pollutants. However, because of continuous generation of novel recalcitrant pollutants due to human activities, it is difficult, if not impossible, for microbes to acquire novel degradation mechanisms through natural evolution. Synthetic biology provides tools to engineer, transform or even re-synthesize an organism purposefully, accelerating transition from unable to able, inefficient to efficient degradation of given pollutants, and therefore, providing new solutions for environmental bioremediation. In this review, we described the pipeline to build chassis cells for the treatment of aromatic pollutants, and presented a proposal to design microbes with emphasis on the strategies applied to modify the target organism at different level. Finally, we discussed challenges and opportunities for future research in this field.

Citing Articles

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