Daytime Glycemic Variability and Frailty in Older Patients with Diabetes: a Pilot Study Using Continuous Glucose Monitoring

Overview

Journal J Korean Med Sci

Specialty General Medicine

Date 2021 Jul 13

PMID 34254474

Citations 6

Authors

Seung Min Chung

Yun Hee Lee

Chang Oh Kim

Ji Yeon Lee

Sang Man Jin

Seung Hyun Yoo

Jun Sung Moon

Kwang Joon Kim

Affiliations

Soon will be listed here.

Abstract

We investigated the relationship between glucose variability and frailty. Forty-eight type 2 diabetic patients aged ≥ 65 years were enrolled. The FRAIL scale was used for frailty assessment, and participants were classified into 'healthy & pre-frail' (n = 24) and 'frail' (n = 24) groups. A continuous glucose monitoring (CGM) system was used for a mean of 6.9 days and standardized CGM metrics were analyzed: mean glucose, glucose management indicator (GMI), coefficient of variation, and time in range, time above range (TAR), and time below range. The demographics did not differ between groups. However, among the CGM metrics, mean glucose, GMI, and TAR in the postprandial periods were higher in the frail group (all < 0.05). After multivariate adjustments, the post-lunch TAR (OR = 1.12, = 0.019) affected the prevalence of frailty. Higher glucose variability with marked daytime postprandial hyperglycemia is significantly associated with frailty in older patients with diabetes.

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